Evidence map›Paper›PMID 33443720›Full record

ArticleMolecular imaging and biology2021

Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [

Bart M de Vries, Tessa Timmers, Emma E Wolters, Rik Ossenkoppele, Sander C J Verfaillie, Robert C Schuit, Philip Scheltens, Wiesje M van der Flier, Albert D Windhorst, Bart N M van Berckel and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Bart M de VriesRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.ORCID 0000-0002-6421-8303
Tessa TimmersRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Emma E WoltersRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Rik OssenkoppeleRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Sander C J VerfaillieAlzheimer Center and Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Robert C SchuitRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Philip ScheltensAlzheimer Center and Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Wiesje M van der FlierAlzheimer Center and Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Albert D WindhorstRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Bart N M van BerckelRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Ronald BoellaardRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Sandeep S V GollaRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. s.golla@amsterdamumc.nl.
Amsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies, particularly because it avoids arterial cannulation. SRTM requires a validated reference region which is obtained by baseline-blocking or displacement studies. Once a reference region is validated, the use should be verified for each new subject. This verification normally requires volume of distribution (V PROCEDURES: Dynamic 130-min [

resultsA low SUV corresponded well with a low V

conclusionsIn situations where dynamic scanning and arterial sampling is not possible, a low SUV

Indexed as

AgedAlzheimer DiseaseAniline CompoundsBrainCarbolinesCase-Control StudiesFemaleFluorine RadioisotopesHumansMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalstau ProteinsThiazolesTissue Distribution2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleAniline CompoundsCarbolinesFluorine RadioisotopesRadiopharmaceuticalstau ProteinsThiazoles[18F]Florbetapir[18F]FlortaucipirAlzheimer’s diseaseSRTMStandardised uptake value

Identifiers

PMID33443720
PMCPMC8277631
OpenAlexW3119404906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.