Evidence map›Paper›PMID 33443665›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Study on different pathogenic factors in different disease stages of patients with Wilson disease.

Xiang-Xue Zhou, Xia Xiao, Haoling Qin, Dingbang Chen, Chao Wu

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiang-Xue ZhouDepartment of Neurology, The East Area of the First Affiliated Hospital, Sun Yat-Sen University, HuangPu East Street, 183#, Guangzhou, Guangdong, China. zxx7317@163.com.ORCID http://orcid.org/0000-0002-6583-9734
Xia XiaoDepartment of Neurology, The East Area of the First Affiliated Hospital, Sun Yat-Sen University, HuangPu East Street, 183#, Guangzhou, Guangdong, China.
Haoling QinImaging Department, The East Area of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510700, China.
Dingbang ChenDepartment of Neurology, The East Area of the First Affiliated Hospital, Sun Yat-Sen University, HuangPu East Street, 183#, Guangzhou, Guangdong, China.
Chao WuDepartment of Neurology, The East Area of the First Affiliated Hospital, Sun Yat-Sen University, HuangPu East Street, 183#, Guangzhou, Guangdong, China.
Sun Yat-sen University · CN

Funding

the National Science Foundation for Young Scholars of China 81500968the Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases 2015B050501003
6 · The paper itself

Abstract

objectiveTo investigate in different stages of patients with Wilson disease (WD), there are different pathogenic factors such as metal deposition, oxidative stress, and inflammatory response in the brain.

methodsA total of 32 untreated WD patients and 10 normal controls were enrolled in the study. The neurological symptoms were evaluated using the modified Young scale. Liver function, metal metabolism, susceptibility-weighted imaging (SWI), diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS) examination were done. The clinical disease stages were divided into metal deposition period, fiber damage period, and neuronal necrosis period according to the imaging results. The content of 24-h urine copper, serum copper, and serum iron; and the levels of catalase (CAT), glutathione peroxidase (GSH-PX), malondialdehyde (MDA), nitric oxide (NO), nitric oxide synthase (NOS), superoxide dismutase (SOD), interleukin (IL-1), and tumor necrosis factor alpha (TNF-α) were detected.

resultsThe contents of urinary copper in WD patients at neuronal necrosis stage were lower than those in patients at the metal deposition stage (P = 0.011) and fiber injury stage (P = 0.023). The contents of NOS (P = 0.039) and NO (P = 0.047) in WD patients at the stage of fiber injury were higher than those of the normal control, while GSH-PX (P = 0.025) and CAT (P = 0.041) were lower in the neuronal necrosis stage. In the stage of neuronal necrosis, the levels of IL-1 (P = 0.030) and TNF-α were higher than those of the normal control (P = 0.042). The neurological symptom scores in patients with fiber injury (P = 0.013) and neuron injury were higher than those with metal deposition (P = 0.026).

conclusionThere are different pathogenic factors in different stages of WD. At the neuronal necrosis stage, copper deposition was decreased in WD patients. In the stage of fiber injury and neuronal necrosis, there is oxidative stress injury in WD patients. In the neuronal necrosis phase, WD patients have an inflammatory response.

Indexed as

Hepatolenticular DegenerationBrainDiffusion Tensor ImagingHumansMagnetic Resonance ImagingVirulence FactorsVirulence FactorsCopper metabolismDisease stageInflammatory responseOxidative stressPathogenic factorWilson disease

Identifiers

PMID33443665
OpenAlexW3120903149

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.