ArticleSurgical case reports2021
Successful treatment of G-CSF-related aortitis with prednisolone during preoperative chemotherapy for breast cancer: a case report.
Article in Surgical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Literature review analysis of aortitis induced by granulocyte-colony stimulating factor.Frontiers in pharmacology · 2024Pooled it
- Improvement of Suspected Paraneoplastic Large-Vessel Vasculitis after Breast Cancer Resection: A Case Report.Surgical case reports · 2026Article
- G-CSF-induced Aortitis in an elderly woman successfully managed with prednisolone: a case report and literature review.Oxford medical case reports · 2025Article
- A Cautionary Note on Pembrolizumab use in Patients with Ascending Aortic Aneurysms.European journal of case reports in internal medicine · 2024Article
- Aortitis Associated with Prophylactic Short-acting Granulocyte Colony-stimulating Factor Administration: A Case Report and Review of the Literature.Internal medicine (Tokyo, Japan) · 2023Review
- Granulocyte colony-stimulating factor-associated aortitis in a woman with breast cancer: a case report.Surgical case reports · 2022Article
- Pegfilgrastim-induced vasculitis of the subclavian and basilar artery complicated by subarachnoid hemorrhage in a breast cancer patient: a case report and review of the literature.Surgical case reports · 2022Article
- Function and Application of Flavonoids in the Breast Cancer.International journal of molecular sciences · 2022Review
- Aortitis and aortic dissection after administration of pegfilgrastim during adjuvant chemotherapy for early breast cancer.International cancer conference journal · 2022Article
- Drug-induced aortitis of the subclavian artery caused by pegfilgrastim: a case report.Surgical case reports · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the introduction of dose-dense therapy, the use of primary pegfilgrastim (PEG-G) has been increasing in breast cancer treatment. A rare side effect of PEG-G is aortitis. We describe a case of PEG-G-induced aortitis. CASE PRESENTATION: The patient was a 43-year-old woman with stage IIA breast cancer. Due to the subtype of triple-negative breast cancer, preoperative dose-dense epirubicin-cyclophosphamide chemotherapy was started. PEG-G was administered on day 3 after the first cycle of epirubicin-cyclophosphamide chemotherapy. On day 11, she had a fever (39.4 °C) and an elevated C-reactive protein level (27.1 mg/dL). Emergency computed tomography revealed diffused wall thickening of the aortic arch without any other signs of infection. Despite administering antibiotics, her general condition and laboratory findings deteriorated until day 18. Based on these observations, she was diagnosed with PEG-G-induced aortitis. Antibiotics were discontinued, and she was treated with prednisolone thereafter. Subsequently, her clinical symptoms and laboratory findings improved around day 39. A second computed tomography scan revealed a decrease in the aortic arch wall thickening, and she was discharged on day 43.
conclusionsWe successfully treated PEG-G-induced aortitis using prednisolone. Although this side effect is rare, cancer patients receiving PEG-G for chemotherapy should be monitored for aortic inflammation.
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