Evidence map›Paper›PMID 33443622›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Novel genetic characteristics of multifocal micronodular pneumocyte hyperplasia (MMPH): a case report with frequent BRAF mutations analyzed by next-generation sequencing supporting benign behaviors of MMPH.

Chihiro Inoue, Ryoko Saito, Satsuki Kishikawa, Takuo Hayashi, Toshio Kumasaka, Takehiro Yamada, Hisashi Oishi, Yuto Yamazaki, Fumiyoshi Fujishima, Mika Watanabe and 1 more

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Chihiro InoueDepartment of Anatomic Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Ryoko SaitoDepartment of Anatomic Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. saitoarlu@patholo2.med.tohoku.ac.jp.ORCID http://orcid.org/0000-0003-3627-1788
Satsuki KishikawaDepartment of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Takuo HayashiDepartment of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Toshio KumasakaDepartment of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan.
Takehiro YamadaDepartment of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
Hisashi OishiDepartment of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
Yuto YamazakiDepartment of Anatomic Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Fumiyoshi FujishimaDepartment of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan.
Mika WatanabeDepartment of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan.
Hironobu SasanoDepartment of Anatomic Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Tohoku University · JPJuntendo University · JPTohoku University Hospital · JPJapanese Red Cross Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A woman in her 30s, who was clinically diagnosed with tuberous sclerosis complex, underwent lung transplantation due to lymphangioleiomyomatosis with concomitant multifocal micronodular pneumocyte hyperplasia (MMPH). Histologically, MMPH lesions demonstrated variety in histology; some showed homogenous cells with mild nuclear atypia and elastic fibers proliferation, and the others showed enlarged nuclei without elastic fibers. Because the natural history of MMPH is not well characterized, we used next-generation sequencing to perform a comprehensive genetic analysis for the MMPH lesions to explore their malignant potential. Regardless of their histological variety, three of four lesions had BRAF missense mutations, especially the types frequently detected in atypical adenomatous hyperplasia that is considered to be benign rather than a precursor of adenocarcinoma. None of them had major driver mutations of lung adenocarcinoma, except for BRAF mutations. In conclusion, our study of the lesions from this patient indicated the benign characteristic of MMPH.

Indexed as

DNA Mutational AnalysisHigh-Throughput Nucleotide SequencingMutation, MissenseAdultAlveolar Epithelial CellsFemaleGenetic Predisposition to DiseaseHumansHyperplasiaLung DiseasesLung TransplantationPhenotypePredictive Value of TestsProto-Oncogene Proteins B-rafTuberous SclerosisBRAF protein, humanProto-Oncogene Proteins B-rafBRAF mutationLymphangioleiomyomatosisMultifocal micronodular pneumocyte hyperplasiaTuberous sclerosis complex

Identifiers

PMID33443622
OpenAlexW3119040269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.