Evidence map›Paper›PMID 33443609›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021

Bone and non-contractile soft tissue changes following open kinetic chain resistance training and testosterone treatment in spinal cord injury: an exploratory study.

M E Holman, G Chang, M P Ghatas, P K Saha, X Zhang, M R Khan, A P Sima, R A Adler, A S Gorgey

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01652040 phase2 / phase3completednot on this map

Effects of Evoked Resistance Training and Testosterone After Spinal Cord Injury

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2012 to 2017Enrolled26ConditionsSpinal Cord InjuryArmsResistance Training and Testosterone Patches, Testosterone Patches
NCT05008484 phase2 / phase3completednot on this map

Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2021 to 2024Enrolled6ConditionsSpinal Cord InjuryArmsNMES, Vitamin D, Passive movement
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Electrical stimulation paradigms on muscle quality and bone mineral density after spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

M E HolmanSpinal Cord Injury and Disorders, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA.ORCID https://orcid.org/0000-0001-9734-2418
G ChangDepartment of Radiology, NYU School of Medicine, New York, NY, 10016, USA.
M P GhatasSpinal Cord Injury and Disorders, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA.ORCID https://orcid.org/0000-0002-8189-3183
P K SahaDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, 52242, USA.
X ZhangDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, 52242, USA.
M R KhanDepartment of Radiology, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA.
A P SimaDepartment of Biostatistics, Virginia Commonwealth University, Richmond, VA, 23284, USA.ORCID https://orcid.org/0000-0001-8426-9987
R A AdlerSpinal Cord Injury and Disorders, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA.
A S GorgeySpinal Cord Injury and Disorders, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA. ashraf.gorgey@va.gov.ORCID https://orcid.org/0000-0002-9157-6034
Hunter Holmes McGuire VA Medical Center · USUniversity of Iowa · USVirginia Commonwealth University · USNew York University · US

Funding

U.S. Department of Veterans Affairs B7867-W
6 · The paper itself

Abstract

Twenty men with spinal cord injury (SCI) were randomized into two 16-week intervention groups receiving testosterone treatment (TT) or TT combined with resistance training (TT + RT). TT + RT appears to hold the potential to reverse or slow down bone loss following SCI if provided over a longer period.

introductionPersons with SCI experience bone loss below the level of injury. The combined effects of resistance training and TT on bone quality following SCI remain unknown.

methodsMen with SCI were randomized into 16-week treatments receiving TT or TT + RT. Magnetic resonance imaging (MRI) of the right lower extremity before participation and post-intervention was used to visualize the proximal, middle, and distal femoral shaft, the quadriceps tendon, and the intermuscular fascia of the quadriceps. For the TT + RT group, MRI microarchitecture techniques were utilized to elucidate trabecular changes around the knee. Individual mixed models were used to estimate effect sizes.

resultsTwenty participants completed the pilot trial. A small effect for yellow marrow in the distal femur was indicated as increases following TT and decreases following TT + RT were observed. Another small effect was observed as the TT + RT group displayed greater increases in intermuscular fascia length than the TT arm. Distal femur trabecular changes for the TT + RT group were generally small in effect (decreased trabecular thickness variability, spacing, and spacing variability; increased network area). Medium effects were generally observed in the proximal tibia (increased plate width, trabecular thickness, and network area; decreased trabecular spacing and spacing variability).

conclusionsThis pilot suggests longer TT + RT interventions may be a viable rehabilitation technique to combat bone loss following SCI. CLINICAL

trial registrationRegistered with clinicaltrials.gov : NCT01652040 (07/27/2012).

Indexed as

Resistance TrainingSpinal Cord InjuriesBone and BonesBone DensityHumansMaleTestosteroneTibiaTestosteroneBone marrow adiposityElectrical stimulationFascia lengthSpinal cord injuryTestosterone treatmentTrabecular bone

Identifiers

PMID33443609
OpenAlexW3120131918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.