Evidence map›Paper›PMID 33443299›Full record

ArticleEuropean journal of heart failure2021

Relationship between body mass index, cardiovascular biomarkers and incident heart failure.

Navin Suthahar, Laura M G Meems, Dion Groothof, Stephan J L Bakker, Ron T Gansevoort, Dirk J van Veldhuisen, Rudolf A de Boer

Open access · hybridAbstract read
In one paragraph

Article in European journal of heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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  11. Effect of body mass index on N-terminal pro-brain natriuretic peptide values in patients with heart failure.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Navin SuthaharDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-7781-2897
Laura M G MeemsDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-8627-7139
Dion GroothofNephrology Division, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-1886-4451
Stephan J L BakkerNephrology Division, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-3356-6791
Ron T GansevoortNephrology Division, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-3223-0906
Dirk J van VeldhuisenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rudolf A de BoerDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-4775-9140
University Medical Center Groningen · NL

Funding

CVON DOSIS 2014-40CVON RED-CVD 2017-11CVON SHE-PREDICTS-HF 2017-21Dutch Kidney FoundationEuropean Research Council ERC CoG 818715NWO VIDI 917.13.350
6 · The paper itself

Abstract

aimsThere are limited data examining whether body mass index (BMI) influences the association between cardiovascular biomarkers and incident heart failure (HF). METHODS AND

resultsThirteen biomarkers representing key HF domains were measured: N-terminal pro-B-type natriuretic peptide (NT-proBNP), mid-regional pro-A-type natriuretic peptide (MR-proANP), cardiac troponin T (cTnT), C-reactive protein, procalcitonin, galectin-3, C-terminal pro-endothelin-1 (CT-proET-1), mid-regional pro-adrenomedullin, plasminogen activator inhibitor-1, copeptin, renin, aldosterone, and cystatin-C. Associations of biomarkers with BMI were examined using linear regression models, and with incident HF using Cox regression models. We selected biomarkers significantly associated with incident HF, and evaluated whether BMI modified these associations. Among 8202 individuals, 41% were overweight (BMI 25-30 kg/m

conclusionsPlasma concentrations of several cardiovascular biomarkers are influenced by obesity. Only NT-proBNP, MR-proANP and cTnT were associated with incident HF, and BMI did not modify these associations. A combination of NT-proBNP and cTnT improves HF risk prediction in overweight and obese individuals.

Indexed as

Heart FailureAdrenomedullinAdultAgedBiomarkersBody Mass IndexFemaleHumansMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsProtein PrecursorsAdrenomedullinBiomarkersNatriuretic Peptide, BrainPeptide FragmentsProtein PrecursorsAssociationsBody mass indexCardiovascular biomarkersGeneral populationHeart failurePredictive value

Identifiers

PMID33443299
PMCPMC8247970
OpenAlexW3119767868

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.