ArticleProceedings of the National Academy of Sciences of the United States of America2021
Reston virus causes severe respiratory disease in young domestic pigs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Sustainability and future outlook of the Philippine pig industry.Journal of advanced veterinary and animal research · 2025Article
- Exploratory Temporal and Evolutionary Insights into theMicroorganisms · 2025Article
- Food security: The ultimate one-health challenge.One health (Amsterdam, Netherlands) · 2024Review
- Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017-2019.Emerging infectious diseases · 2024Article
- Experimental Infection of Bundibugyo Virus in Domestic Swine Leads to Viral Shedding with Evidence of Intraspecies Transmission.Transboundary and emerging diseases · 2024Article
- Pathogenicity of Lloviu and Bombali Viruses in Type I Interferon Receptor Knockout Mice.The Journal of infectious diseases · 2023Article
- Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research.Viruses · 2023Review
- Swine production: how sustainable is sustainability?Animal frontiers : the review magazine of animal agriculture · 2022Article
- Three-Week Old Pigs Are Not Susceptible to Productive Infection with SARS-COV-2.Microorganisms · 2022Article
- Recombinant Lloviu virus as a tool to study viral replication and host responses.PLoS pathogens · 2022Article
- Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment.ILAR journal · 2022Article
- Macrophage infection, activation, and histopathological findings in ebolavirus infection.Frontiers in cellular and infection microbiology · 2022Review
- Environmental implications and evidence of natural products from dental calculi of a Neolithic-Chalcolithic community (central Italy).Scientific reports · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Reston virus (RESTV), an ebolavirus, causes clinical disease in macaques but has yet only been associated with rare asymptomatic infections in humans. Its 2008 emergence in pigs in the Philippines raised concerns about food safety, pathogenicity, and zoonotic potential, questions that are still unanswered. Until today, the virulence of RESTV for pigs has remained elusive, with unclear pathogenicity in naturally infected animals and only one experimental study demonstrating susceptibility and evidence for shedding but no disease. Here we show that combined oropharyngeal and nasal infection of young (3- to 7-wk-old) Yorkshire cross pigs with RESTV resulted in severe respiratory disease, with most animals reaching humane endpoint within a week. RESTV-infected pigs developed severe cyanosis, tachypnea, and acute interstitial pneumonia, with RESTV shedding from oronasal mucosal membranes. Our studies indicate that RESTV should be considered a livestock pathogen with zoonotic potential.
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Registered trials
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