Evidence map›Paper›PMID 33443205›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Endogenous membrane stress induces T6SS activity in

Anne-Sophie Stolle, Bradley Thomas Meader, Jonida Toska, John J Mekalanos

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. T6SS mutants exploit itaconate to support infection of phagocytes.bioRxiv : the preprint server for biology · 2026
    Article
  3. ThemBio · 2026
    Article
  4. Genetic Diversity ofMicroorganisms · 2025
    Article
  5. Article
  6. Science advances · 2025
    Article
  7. Review
  8. Article
  9. Microbiology (Reading, England) · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. The Wsp system ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Antimicrobial Weapons of Pseudomonas aeruginosa.Advances in experimental medicine and biology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Anne-Sophie StolleDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-6341-5575
Bradley Thomas MeaderDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0003-0771-8675
Jonida ToskaDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-6115-8862
John J MekalanosDepartment of Microbiology, Harvard Medical School, Boston, MA 02115; john_mekalanos@hms.harvard.edu.
Harvard University · US

Funding

Genetic analysis of toxinogenesis of Vibrio choleraeR37AI018045 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI John Joseph Mekalanos · 1989 to 2026
$12.8M
COORDINATE REGULATION OF BACTERIAL VIRULENCE FACTORSR01AI026289 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MEKALANOS, JOHN JOSEPH · 1988 to 2018
$8.3M
NIAID NIH HHS R01 AI026289NIAID NIH HHS R37 AI018045
6 · The paper itself

Abstract

The type 6 secretion system (T6SS) is a dynamic organelle encoded by many gram-negative bacteria that can be used to kill competing bacterial prey species in densely occupied niches. Some predatory species, such as

Indexed as

CRISPR-Cas SystemsBacterial Outer Membrane ProteinsCell MembraneCell SurvivalGene Knockdown TechniquesGenes, EssentialGene SilencingGenotypePeriplasmic ProteinsPhenotypePseudomonas aeruginosaRNA-SeqSignal TransductionStress, PhysiologicalType VI Secretion SystemsVibrio choleraeBacterial Outer Membrane ProteinsPeriplasmic ProteinsType VI Secretion SystemsCRISPRiessential genemembrane stressT6SS activation

Identifiers

PMID33443205
PMCPMC7817224
OpenAlexW3117502169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.