ArticleProceedings of the National Academy of Sciences of the United States of America2021
Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- A computational architecture incorporating shallow brain networks: integrating parallel cortical and subcortical processing.Current research in neurobiology · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Article
- Mesoscale imaging of the human cerebellum reveals converging regional specialization of its morphology, vasculature, and cytoarchitecture.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cerebellar tDCS Modulates Corticocortical Functional Networks in a Regionally Specific Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex.eLife · 2025Article
- Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex.bioRxiv : the preprint server for biology · 2025Article
- Stage-dependent cerebrocerebellar communication during sensorimotor processing.Nature communications · 2025Article
- Diverse and flexible behavioral strategies arise in recurrent neural networks trained on multisensory decision making.PLoS computational biology · 2025Article
- Cortical networks with multiple interneuron types generate oscillatory patterns during predictive coding.PLoS computational biology · 2025Article
- Cerebellar Activity Affects Distal Cortical Physiology and Synaptic Plasticity in a Human Parietal-Motor Pathway Associated with Motor Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Relationships of functional connectivity of motor cortex, primary somatosensory cortex, and cerebellum to balance performance in middle-aged and older adults.Neurobiology of aging · 2025Article
- Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8).Neurobiology of disease · 2025Article
- Cerebellar control of targeted tongue movements.The Journal of physiology · 2025Article
- Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques.eLife · 2025Article
- The cerebellum engages multiple pre-motor pathways through a divergent-convergent architecture to shape whisker dynamics.Frontiers in neural circuits · 2025Article
- Distinct Functional Classes of CA1 Hippocampal Interneurons Are Modulated by Cerebellar Stimulation in a Coordinated Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model.Protein & cell · 2024Article
- Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice.Cerebellum (London, England) · 2024Review
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activity of sensory and motor cortices is essential for sensorimotor integration. In particular, coherence between these areas may indicate binding of critical functions like perception, motor planning, action, or sleep. Evidence is accumulating that cerebellar output modulates cortical activity and coherence, but how, when, and where it does so is unclear. We studied activity in and coherence between S1 and M1 cortices during whisker stimulation in the absence and presence of optogenetic Purkinje cell stimulation in crus 1 and 2 of awake mice, eliciting strong simple spike rate modulation. Without Purkinje cell stimulation, whisker stimulation triggers fast responses in S1 and M1 involving transient coherence in a broad spectrum. Simultaneous stimulation of Purkinje cells and whiskers affects amplitude and kinetics of sensory responses in S1 and M1 and alters the estimated S1-M1 coherence in theta and gamma bands, allowing bidirectional control dependent on behavioral context. These effects are absent when Purkinje cell activation is delayed by 20 ms. Focal stimulation of Purkinje cells revealed site specificity, with cells in medial crus 2 showing the most prominent and selective impact on estimated coherence, i.e., a strong suppression in the gamma but not the theta band. Granger causality analyses and computational modeling of the involved networks suggest that Purkinje cells control S1-M1 phase consistency predominantly via ventrolateral thalamus and M1. Our results indicate that activity of sensorimotor cortices can be dynamically and functionally modulated by specific cerebellar inputs, highlighting a widespread role of the cerebellum in coordinating sensorimotor behavior.
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