ArticleProceedings of the National Academy of Sciences of the United States of America2021
Social isolation uncovers a circuit underlying context-dependent territory-covering micturition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
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- A novel behavioral paradigm for odor-induced voluntary urination in mice.Scientific reports · 2026Article
- Factors Modulating the Effects of Juvenile Social Isolation on Adult Social Behavior in Rodents.Developmental psychobiology · 2026Review
- Diurnal regulation of urinary behavior and gene expression in aged mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Article
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- Enkephalinergic Neurons in Barrington's Nucleus Gate Sex-Specific Control of Micturition.Research square · 2025Article
- Behavioral tests for the assessment of social hierarchy in mice.Frontiers in behavioral neuroscience · 2025Review
- Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Three-dimensional mapping in multi-samples with large-scale imaging and multiplexed post staining.Communications biology · 2023Article
- Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents.Molecular autism · 2022Review
- BoutonNet: an automatic method to detect anterogradely labeled presynaptic boutons in brain tissue sections.Brain structure & function · 2022Article
- Neural circuit control of innate behaviors.Science China. Life sciences · 2022Review
- Advancing our understanding of the neural control of the female human urethra.Neurourology and urodynamics · 2022Article
- Ventrolateral Periaqueductal Gray Neurons Are Active During Urination.Frontiers in cellular neuroscience · 2022Article
- Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases.Cell reports · 2021Article
- 3D Whole-Brain Imaging Approaches to Study Brain Tumors.Cancers · 2021Review
- Choosing to urinate. Circuits and mechanisms underlying voluntary urination.Current opinion in neurobiology · 2020Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The release of urine, or micturition, serves a fundamental physiological function and, in many species, is critical for social communication. In mice, the pattern of urine release is modulated by external and internal factors and transmitted to the spinal cord via the pontine micturition center (PMC). Here, we exploited a behavioral paradigm in which mice, depending on strain, social experience, and sensory context, either vigorously cover an arena with small urine spots or deposit urine in a few isolated large spots. We refer to these micturition modes as, respectively, high and low territory-covering micturition (TCM) and find that the presence of a urine stimulus robustly induces high TCM in socially isolated mice. Comparison of the brain networks activated by social isolation and by urine stimuli to those upstream of the PMC identified the lateral hypothalamic area as a potential modulator of micturition modes. Indeed, chemogenetic manipulations of the lateral hypothalamus can switch micturition behavior between high and low TCM, overriding the influence of social experience and sensory context. Our results suggest that both inhibitory and excitatory signals arising from a network upstream of the PMC are integrated to determine context- and social-experience-dependent micturition patterns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.