ArticleJournal of neurointerventional surgery2021
Health economic impact of first-pass success among patients with acute ischemic stroke treated with mechanical thrombectomy: a United States and European perspective.
Article in Journal of neurointerventional surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Health Economic Impact of Incomplete Reperfusion Patterns After Endovascular Thrombectomy in Acute Ischemic Stroke.Clinical neuroradiology · 2026Article
- Key to better outcomes in stroke intervention: early versus complete reperfusion in first pass recanalization.Journal of neurology · 2025Observational
- Placing the balloon-guide catheter in the high cervical segment of the internal carotid artery is associated with improved recanalization.Journal of neurointerventional surgery · 2025Article
- Impact of the Recanalization Level and the First-Pass Effect on Functional Outcomes in Patients After M2 MCA Occlusion Thrombectomy.Journal of clinical medicine · 2025Article
- Relationship between first pass effect NLR and PLR in mechanical thrombectomy for acute anterior circulation large-vessel occlusion.Frontiers in neurology · 2025Article
- Effects of manual carotid compression in endovascular thrombectomy for acute anterior circulation large-vessel occlusion: a multicenter, propensity score-matching study.Frontiers in neurology · 2025Article
- Article
- Epidemiology, organization, diagnosis and treatment of acute ischemic stroke.European journal of radiology open · 2023Article
- Predictors of functional outcome after thrombectomy for M2 occlusions: a large scale experience from clinical practice.Scientific reports · 2023Article
- First-Pass Effect With Aspiration Thrombectomy With the Penumbra System in Patients With Acute Ischemic Stroke: A Core Laboratory-Adjudicated Subset Analysis of the COMPLETE Registry.Stroke (Hoboken, N.J.) · 2023Article
- First-Pass Recanalization with EmboTrap II in Acute Ischemic Stroke (FREE-AIS): A Multicenter Prospective Study.Korean journal of radiology · 2023Article
- INFluence of Revascularization Attempts on Clinical Outcomes of Mechanical Thrombectomy Patients and its Economic BURDEN.Stroke (Hoboken, N.J.) · 2022Article
- Importance of First Pass Reperfusion in Endovascular Stroke Care - Insights From Thrombectomy and Aneurysm Registry (STAR).Stroke (Hoboken, N.J.) · 2022Article
- Article
- First Pass Effect and Location of Occlusion in Recanalized MCA M1 Occlusions.Frontiers in neurology · 2022Article
- Mechanical Thrombectomy in Stroke. Experience from Switching from Stent Retriever Only to Stent Retriever Combined with Aspiration Catheter.Journal of clinical medicine · 2021Article
- First-Pass Reperfusion by Mechanical Thrombectomy in Acute M1 Occlusion: The Size of Retriever Matters.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFirst-pass effect (FPE), restoring complete or near complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2c-3) in a single pass, is an independent predictor for good functional outcomes in the endovascular treatment of acute ischemic stroke. The economic implications of achieving FPE have not been assessed.
objectiveTo assess the economic impact of achieving complete or near complete reperfusion after the first pass.
methodsPost hoc analyses were conducted using ARISE II study data. The target population consisted of patients in whom mTICI 2c-3 was achieved, stratified into two groups: (1) mTICI 2c-3 achieved after the first pass (FPE group) or (2) after multiple passes (non-FPE group). Baseline characteristics, clinical outcomes, and healthcare resource use were compared between groups. Costs from peer-reviewed literature were applied to assess cost consequences from the perspectives of the United States (USA), France, Germany, Italy, Spain, Sweden, and United Kingdom (UK).
resultsAmong patients who achieved mTICI 2c-3 (n=172), FPE was achieved in 53% (n=91). A higher proportion of patients in the FPE group reached good functional outcomes (90-day modified Rankin Scale score 0-2 80.46% vs 61.04%, p<0.01). The patients in the FPE group had a shorter mean length of stay (6.10 vs 9.48 days, p<0.01) and required only a single stent retriever, whereas 35% of patients in the non-FPE group required at least one additional device. Driven by improvement in clinical outcomes, the FPE group had lower procedural/hospitalization-related (24-33% reduction) and annual care (11-27% reduction) costs across all countries.
conclusionsFPE resulted in improved clinical outcomes, translating into lower healthcare resource use and lower estimated costs.
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