Evidence map›Paper›PMID 33443093›Full record

ArticleJournal of cell science2021

AMPK signaling mediates synphilin-1-induced hyperphagia and obesity in

Jingnan Liu, Xiaobo Wang, Rui Ma, Tianxia Li, Gongbo Guo, Bo Ning, Timothy H Moran, Wanli W Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jingnan LiuDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Xiaobo WangDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Rui MaDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.ORCID 0000-0002-9457-849X
Tianxia LiDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Gongbo GuoDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Bo NingDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Timothy H MoranDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Wanli W SmithDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA wsmith60@jhmi.edu.ORCID 0000-0002-6482-5154
Johns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

Synphilin-1 and ObesityR01DK083410 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI SMITH, WANLI W · 2010 to 2014
$1.7M
NIDDK NIH HHS R01 DK083410
6 · The paper itself

Abstract

Expression of synphilin-1 in neurons induces hyperphagia and obesity in a

Indexed as

AMP-Activated Protein KinasesDrosophilaHyperphagiaObesityAnimalsAnimals, Genetically ModifiedCarrier ProteinsHumansNerve Tissue ProteinsSignal TransductionAMP-Activated Protein KinasesCarrier ProteinsNerve Tissue ProteinsSNCAIP protein, humanAMPKEnergy homeostasisHyperphagiaObesitySynphilin-1

Identifiers

PMID33443093
PMCPMC7875497
OpenAlexW3115964085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.