Evidence map›Paper›PMID 33443088›Full record

ArticleJournal of virology2021

Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell Immunity.

Eunok Lee, Kerrie Sandgren, Gabriel Duette, Vicki V Stylianou, Rajiv Khanna, John-Sebastian Eden, Emily Blyth, David Gottlieb, Anthony L Cunningham, Sarah Palmer

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  6. Impaired and restored CD8Frontiers in immunology · 2025
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  15. Molecular characterization of SARS-CoV-2 nucleocapsid protein.Frontiers in cellular and infection microbiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Eunok Lee *Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia eunok.lee@sydney.edu.au.ORCID 0000-0002-5528-3859
Kerrie Sandgren *Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Gabriel Duette *Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Vicki V StylianouCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Rajiv KhannaFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
John-Sebastian EdenCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.ORCID 0000-0003-1374-3551
Emily BlythSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
David GottliebSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Anthony L Cunningham *Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Sarah Palmer *Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
The University of Sydney · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is critical for measuring the duration of immunity to this disease and assessing the efficacy of vaccine candidates. These assays need to target conserved regions of SARS-CoV-2 global variants and avoid cross-reactivity to seasonal human coronaviruses. To contribute to this effort, we employed an

Indexed as

Amino Acid SequenceAntigen PresentationCD8-Positive T-LymphocytesComputational BiologyCoronavirusCoronavirus Nucleocapsid ProteinsCOVID-19Epitopes, T-LymphocyteHLA AntigensHumansImmunity, CellularMutationPhosphoproteinsProtein BindingSARS-CoV-2Species SpecificityCoronavirus Nucleocapsid ProteinsEpitopes, T-LymphocyteHLA Antigensnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19 vaccinesdiagnostic toolshighly networked/conserved T-cell epitope derived peptidesnucleocapsid and spike proteinsprotein networkSARS-CoV-2T-cell effector/polyfunctionality

Identifiers

PMID33443088
PMCPMC8579755
OpenAlexW3113621889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.