ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Contribution of the Pulvinar and Lateral Geniculate Nucleus to the Control of Visually Guided Saccades in Blindsight Monkeys.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- From error to evidence: blindsight in the making†.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight.Current biology : CB · 2026Article
- Widespread Corticothalamic Connectivity Identifies the Inferior Pulvinar as a Central Node in Visual Network Architecture.bioRxiv : the preprint server for biology · 2026Article
- Pulvinar-posterior superior temporal sulcus connectivity contributes to non-conscious emotion processing in affective blindsight.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Neural correlates of vestibular adaptation in cosmonauts after long duration spaceflight.NPJ microgravity · 2025Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Pathways Mediating Blindsight After V1 Injury: A Systematic Review of Human and Monkey Studies.Basic and clinical neuroscience · 2025Review
- Complementary Organization of Mouse Driver and Modulator Cortico-thalamo-cortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Lamination, Borders, and Thalamic Projections of the Primary Visual Cortex in Human, Non-Human Primate, and Rodent Brains.Brain sciences · 2024Review
- Network Localization of Unconscious Visual Perception in Blindsight.Annals of neurology · 2022Article
- Remodeling of lateral geniculate nucleus projections to extrastriate area MT following long-term lesions of striate cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phylogenetic view of the compensatory mechanisms in motor and sensory systems after neuronal injury.Current research in neurobiology · 2022Review
- Neurochemical changes in the primate lateral geniculate nucleus following lesions of striate cortex in infancy and adulthood: implications for residual vision and blindsight.Brain structure & function · 2021Article
- Volume reduction without neuronal loss in the primate pulvinar complex following striate cortex lesions.Brain structure & function · 2021Article
- The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action.Current biology : CB · 2021Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
After damage to the primary visual cortex (V1), conscious vision is impaired. However, some patients can respond to visual stimuli presented in their lesion-affected visual field using residual visual pathways bypassing V1. This phenomenon is called "blindsight." Many studies have tried to identify the brain regions responsible for blindsight, and the pulvinar and/or lateral geniculate nucleus (LGN) are suggested to play key roles as the thalamic relay of visual signals. However, there are critical problems regarding these preceding studies in that subjects with different sized lesions and periods of time after lesioning were investigated; furthermore, the ability of blindsight was assessed with different measures. In this study, we used double dissociation to clarify the roles of the pulvinar and LGN by pharmacological inactivation of each region and investigated the effects in a simple task with visually guided saccades (VGSs) using monkeys with a unilateral V1 lesion, by which nearly all of the contralesional visual field was affected. Inactivating either the ipsilesional pulvinar or LGN impaired VGS toward a visual stimulus in the affected field. In contrast, inactivation of the contralesional pulvinar had no clear effect, but inactivation of the contralesional LGN impaired VGS to the intact visual field. These results suggest that the pulvinar and LGN play key roles in performing the simple VGS task after V1 lesioning, and that the visuomotor functions of blindsight monkeys were supported by plastic changes in the visual pathway involving the pulvinar, which emerged after V1 lesioning.
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