Evidence map›Paper›PMID 33443052›Full record

ArticleJournal of the American Society of Nephrology : JASN2021

Dysregulated Dynein-Mediated Trafficking of Nephrin Causes INF2-related Podocytopathy.

Hua Sun, Chandra Perez-Gill, Johannes S Schlöndorff, Balajikarthick Subramanian, Martin R Pollak

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Mechanisms of podocyte injury in genetic kidney disease.Pediatric nephrology (Berlin, Germany) · 2025
    Review
  3. Article
  4. Podocytes in health and glomerular disease.Frontiers in cell and developmental biology · 2025
    Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hua SunDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-8233-7755
Chandra Perez-GillDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Johannes S SchlöndorffDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9973-9731
Balajikarthick SubramanianDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Martin R PollakDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Beth Israel Deaconess Medical Center · USUniversity of Iowa · US

Funding

INF2 in kidney function and dysfunctionR01DK088826 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HENRY N HIGGS, MARTIN R. POLLAK · 2010 to 2026
$6.3M
RESEARCH TRAINING IN PEDIATRIC NEPHROLOGYT32DK007726 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI BRISCOE, DAVID M. · 1994 to 2023
$5.9M
NIDDK NIH HHS R01 DK088826NIDDK NIH HHS T32 DK007726
6 · The paper itself

Abstract

backgroundFSGS caused by mutations in

methodsLive cell and quantitative imaging, fluorescent and surface biotinylation-based trafficking assays in cultured podocytes, and a new puromycin aminoglycoside nephropathy model of

resultsPathogenic

conclusions

Indexed as

AnimalsCell Culture TechniquesCytoplasmic DyneinsForminsGlomerulosclerosis, Focal SegmentalMembrane ProteinsMiceMutationPodocytesProtein TransportCytoplasmic DyneinsDYNLL1 protein, mouseForminsINF2 protein, mouseMembrane Proteinsnephrincytoskeletongenetic renal diseasepodocyte

Identifiers

PMID33443052
PMCPMC8054882
OpenAlexW3113859209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.