ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Age- and sex-dependent changes of resting amygdalar activity in individuals free of clinical cardiovascular disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Altered Neurovascular Coupling Dynamics During Dobutamine-Induced Acute Stress.Brain and behavior · 2026Article
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- Age modulates the link between stress-related neural activity and mortality.Nature communications · 2025Article
- Imaging of the brain-heart axis: prognostic value in a European setting.European heart journal · 2024Article
- Sex Differences in Outcomes of Acute Myocardial Injury After Stroke.Journal of the American Heart Association · 2024Observational
- Heart-brain interactions in cardiac and brain diseases: why sex matters.European heart journal · 2022Review
- The brain connection between stress and heart: a convincing research opportunity to reduce risk and gender disparity in cardiovascular disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAmygdalar metabolic activity was shown to independently predict cardiovascular outcomes. However, little is known about age- and sex-dependent variability in neuronal stress responses among individuals free of cardiac disease. This study sought to assess age- and sex-specific differences of resting amygdalar metabolic activity in the absence of clinical cardiovascular disease.
methodsAmygdalar metabolic activity was assessed in 563 patients who underwent multimodality imaging by
resultsAfter exclusion of 294 patients with structural or functional cardiovascular pathologies, 269 patients (128 women) remained in the final population.
conclusionAmygdalar activity decreases with age in men, but not in women. The use of amygdalar activity for cardiovascular risk stratification merits consideration of inherent age- and sex-dependent variability.
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