Evidence map›Paper›PMID 33442698›Full record

ArticlebioRxiv : the preprint server for biology2021

Molecular dynamics simulations and functional studies reveal that hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2 expressing cells.

Liqun Zhang, Santosh K Ghosh, Shrikanth C Basavarajappa, Jeannine Muller-Greven, Jackson Penfield, Ann Brewer, Parameswaran Ramakrishnan, Matthias Buck, Aaron Weinberg

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 25 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Liqun ZhangChemical Engineering, Tennessee Technological University, Cookeville, TN 38505.
Santosh K GhoshBiological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44124.
Shrikanth C BasavarajappaDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44124.
Jeannine Muller-GrevenDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44124.
Jackson PenfieldChemical Engineering, Tennessee Technological University, Cookeville, TN 38505.
Ann BrewerChemical Engineering, Tennessee Technological University, Cookeville, TN 38505.
Parameswaran RamakrishnanDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44124.
Matthias BuckDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44124.
Aaron WeinbergBiological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44124.
Case Western Reserve University · USTennessee Technological University · US

Funding

Structure and function of plexin - co-receptor interactionsR01EY029169 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI BUCK, MATTHIAS · 2018 to 2021
$2.1M
Transcriptional regulation by O-GlcNAcylation in T lymphocytesR01AI116730 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI RAMAKRISHNAN, PARAMESWARAN · 2016 to 2020
$2.0M
Regulation of B cell function and antibody class switching by c-Rel O-GlcNAcylationR21AI144264 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI RAMAKRISHNAN, PARAMESWARAN · 2019 to 2020
$441k
Novel molecular agents targeting NF-κB c-Rel O-GlcNAcylation for the treatment of acute myeloid leukemia.R21CA246194 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI PARAMESWARAN, RESHMI, RAMAKRISHNAN, PARAMESWARAN · 2020 to 2021
$428k
NCI NIH HHS R21 CA246194NEI NIH HHS R01 EY029169NIAID NIH HHS R01 AI116730NIAID NIH HHS R21 AI144264
6 · The paper itself

Abstract

New approaches to complement vaccination are needed to combat the spread of SARS-CoV-2 and stop COVID-19 related deaths and long-term medical complications. Human beta defensin 2 (hBD-2) is a naturally occurring epithelial cell derived host defense peptide that has antiviral properties. Our comprehensive

Indexed as

ACE2 receptorCOVID-19Human beta defensin-2 (hBD-2)receptor binding domain (RBD)SARS-CoV-2

Identifiers

PMID33442698
PMCPMC7805467
OpenAlexW3118794874

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.