Evidence map›Paper›PMID 33442692›Full record

ArticlebioRxiv : the preprint server for biology2022

Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic.

Hazel Stewart, Roberta Palmulli, Kristoffer H Johansen, Naomi McGovern, Ola M Shehata, George W Carnell, Hannah K Jackson, Jin S Lee, Jonathan C Brown, Thomas Burgoyne and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Hazel StewartDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
Roberta PalmulliDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
Kristoffer H JohansenDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
Naomi McGovernDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
Ola M ShehataDepartment of Biomedical Science, University of Sheffield, Firth Court, Sheffield. S10 2TN. UK.
George W CarnellDepartment of Veterinary Medicine, University of Cambridge, Cambridge. CB3 0ES. UK.
Hannah K JacksonDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
Jin S LeeDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
Jonathan C BrownDepartment of Infectious Disease, Imperial College London, London. W2 1PG. UK.
Thomas BurgoyneRoyal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London. SW3 6NP. UK.
Jonathan L HeeneyDepartment of Veterinary Medicine, University of Cambridge, Cambridge. CB3 0ES. UK.
Klaus OkkenhaugDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
Andrew E FirthDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
Andrew A PedenDepartment of Biomedical Science, University of Sheffield, Firth Court, Sheffield. S10 2TN. UK.
James R EdgarDepartment of Pathology, University of Cambridge, Cambridge. CB2 1QP. UK.
University of Cambridge · GBUniversity of Sheffield · GBGuy's and St Thomas' NHS Foundation Trust · GBImperial College London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the

Indexed as

double membrane vesiclesORF3arestriction factorSARS-CoV-2spikeTetherin

Identifiers

PMID33442692
PMCPMC7805449
OpenAlexW3119286183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.