Evidence map›Paper›PMID 33442683›Full record

ArticlebioRxiv : the preprint server for biology2021

M S Nair, Y Huang, D A Fidock, S J Polyak, J Wagoner, M J Towler, P J Weathers

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

M S NairAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Y HuangAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
D A FidockDepartment of Microbiology and Immunology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
S J PolyakDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98104.
J WagonerDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98104.
M J TowlerDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
P J WeathersDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
Aaron Diamond AIDS Research Center · USUniversity of Washington · USWorcester Polytechnic Institute · USColumbia University Irving Medical Center · US

Funding

Urgent Covid-19 Revision to the Center for High-Throughput Functional Annotation of Natural ProductsU41AT008718 · NCCIH · UT SOUTHWESTERN MEDICAL CENTER · PI CECH, NADJA B, LININGTON, ROGER G · 2015 to 2024
$10.1M
Study how the liver alters bioavailability of artemisinin when delivered from the dried leaves of the plant Artemisia annua vs as pure drug.R15AT008277 · NCCIH · WORCESTER POLYTECHNIC INSTITUTE · PI WEATHERS, PAMELA J · 2014 to 2018
$953k
NCCIH NIH HHS R15 AT008277NCCIH NIH HHS U41 AT008718
6 · The paper itself

Abstract

ethnopharmacological relevanceAIM OF THE STUDY: SARS-CoV-2 (the cause of Covid-19) globally has infected and killed millions of people. Because of the broad-spectrum antiviral activity of artemisinin that includes blockade of SARS-CoV-1, we queried whether MATERIALS AND

methodsUsing Vero E6 and Calu-3 cells, we measured anti viral activity SARS-CoV-2 activity against fully infectious virusof dried leaf extracts of seven cultivars of

resultsHot-water leaf extracts based on artemisinin, total flavonoids, or dry leaf mass showed antiviral activity with IC

conclusions

Indexed as

amodiaquineAmodiaquineartemetherArtemetherArtemisia annuaartemisininArtemisininartesunateArtesunateCovid-19DeoxyartemisinindihydroartemisininDihydroartemisininSARS-CoV-2

Identifiers

PMID33442683
PMCPMC7805440
OpenAlexW3118982769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.