Evidence map›Paper›PMID 33442680›Full record

ArticlebioRxiv : the preprint server for biology2021

Extracellular vimentin as a target against SARS-CoV-2 host cell invasion.

Łukasz Suprewicz, Maxx Swoger, Sarthak Gupta, Ewelina Piktel, Fitzroy J Byfield, Daniel V Iwamoto, Danielle Germann, Joanna Reszeć, Natalia Marcińczyk, Robert J Carroll and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 23 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Łukasz SuprewiczDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, Poland.
Maxx SwogerPhysics Department and BioInspired Institute, Syracuse University.
Sarthak GuptaPhysics Department and BioInspired Institute, Syracuse University.
Ewelina PiktelDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, Poland.
Fitzroy J ByfieldInstitute for Medicine and Engineering and Department of Physiology, University of Pennsylvania.
Daniel V IwamotoInstitute for Medicine and Engineering and Department of Physiology, University of Pennsylvania.
Danielle GermannPhysics Department and BioInspired Institute, Syracuse University.
Joanna ReszećDepartment of Medical Pathomorphology, Medical University of Białystok, PL-15269 Białystok, Poland.
Natalia MarcińczykDepartment of Biopharmacy, Medical University of Białystok, Białystok, Poland.
Robert J CarrollPhysics Department and BioInspired Institute, Syracuse University.
Marzena LenartMałopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland.
Krzysztof PyreMałopolska Centre of Biotechnology; Jagiellonian University; Kraków, Poland.
Paul JanmeyInstitute for Medicine and Engineering and Department of Physiology, University of Pennsylvania.
J M SchwarzPhysics Department and BioInspired Institute, Syracuse University.
Robert BuckiDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, Poland.
Alison PattesonPhysics Department and BioInspired Institute, Syracuse University.
Medical University of Białystok · PLSyracuse University · USUniversity of Pennsylvania · USJagiellonian University · PLIndian Creek Farm · US

Funding

Structural basis of the specific protein-protein interactions underlying IF assemP01GM096971 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDMAN, ROBERT D · 2011 to 2021
$16.8M
Regulation of cell, tissue, and nucleus function by mechanical properties of biopolymer networksR35GM136259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Paul A Janmey · 2020 to 2026
$3.2M
NIGMS NIH HHS P01 GM096971NIGMS NIH HHS R35 GM136259
6 · The paper itself

Abstract

Infection of human cells by pathogens, including SARS-CoV-2, typically proceeds by cell surface binding to a crucial receptor. In the case of SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) has been identified as a necessary receptor, but not all ACE2-expressing cells are equally infected, suggesting that other extracellular factors are involved in host cell invasion by SARS-CoV-2. Vimentin is an intermediate filament protein that is increasingly recognized as being present on the extracellular surface of a subset of cell types, where it can bind to and facilitate pathogens' cellular uptake. Here, we present evidence that extracellular vimentin might act as a critical component of the SARS-CoV-2 spike protein-ACE2 complex in mediating SARS-CoV-2 cell entry. We demonstrate direct binding between vimentin and SARS-CoV-2 pseudovirus coated with the SARS-CoV-2 spike protein and show that antibodies against vimentin block

Identifiers

PMID33442680
PMCPMC7805437
OpenAlexW3158241969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.