Evidence map›Paper›PMID 33442618›Full record

ArticleEuropean heart journal. Case reports2020

Antiepileptic rufinamide and QTc interval shortening in a patient with long QT syndrome: case report.

Tapas Mondal, Kristen Sullivan, Syam Divakaramenon, Robert M Hamilton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Tapas MondalDivision of Cardiology, Department of Pediatrics, McMaster University, Health Sciences Centre, 3A 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-2077-1710
Kristen SullivanDepartment of Medicine, McMaster University, Health Sciences Centre, 4V33 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada.
Syam DivakaramenonDivision of Electrophysiology, Department of Cardiology, McMaster University, HHSC, Hamilton General Hospital Site, 502, McMaster Clinic, 237 Barton St. E., Hamilton, ON L8L 2X2, Canada.
Robert M HamiltonDepartment of Pediatrics (Cardiology), The Hospital for Sick Children, Room 1725D, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.ORCID 0000-0002-5344-1278
Health Sciences Centre · CAHamilton General Hospital · CAHospital for Sick Children · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited pharmacologic therapy to reduce the QT interval in hereditary long QT syndrome (LQTS). CASE SUMMARY: We describe a child with Allan-Herndon-Dudley syndrome, Lennox-Gastaut epileptic syndrome (LGS), and LQTS Type 1 (LQTS1). Rufinamide was added to his antiepileptic medications to improve seizure control and was noted to be associated with a marked improvement in electrocardiogram QT interval. To the best of our knowledge, this is the first reported case of successful pharmacologic shortening of the QT interval in LQTS1. DISCUSSION: This case report highlights the potential benefits of rufinamide, a drug associated with mild QT shortening in normal individuals, to markedly reduce and normalize QT duration in a subject with LQTS1.

Indexed as

Case reportLong QT syndromeRufinamide

Identifiers

PMID33442618
PMCPMC7793134
OpenAlexW3106754853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.