Evidence map›Paper›PMID 33442584›Full record

ArticleDigital biomarkers2020

The Collaborative Aging Research Using Technology Initiative: An Open, Sharable, Technology-Agnostic Platform for the Research Community.

Zachary Beattie, Lyndsey M Miller, Carlos Almirola, Wan-Tai M Au-Yeung, Hannah Bernard, Kevin E Cosgrove, Hiroko H Dodge, Charlene J Gamboa, Ona Golonka, Sarah Gothard and 23 more

Open access · goldAbstract read
In one paragraph

Article in Digital biomarkers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
19.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Observational
  5. Article
  6. Non-linear associations between sleep duration and plasma p-tau181 in the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Developing digital health technologies for frontotemporal degeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  16. Article
  17. Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 6 institutions in 2 countries.

Zachary BeattieOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Lyndsey M MillerOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Carlos AlmirolaCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Wan-Tai M Au-YeungOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Hannah BernardOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Kevin E CosgroveOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Hiroko H DodgeOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Charlene J GamboaRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Ona GolonkaOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Sarah GothardOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Sam HarbisonOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Stephanie IrishOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Judith KornfeldOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Jonathan LeeOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Jennifer MarcoeOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Nora C MattekOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Charlie QuinnOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Christina ReynoldsOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Thomas RileyOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Nathaniel RodriguesOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Nicole SharmaOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Mary Alice SiquelandOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Neil W ThomasDepartment of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Timothy TrutyRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Rachel WallOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Katherine WildOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Chao-Yi WuOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Jason KarlawishDepartment of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nina B SilverbergDivision of Neuroscience, National Institute on Aging, National Institute of Health, Bethesda, Maryland, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Sara CzajaCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Lisa C SilbertOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Jeffrey KayeOregon Center for Aging & Technology, Oregon Health & Science University, Portland, Oregon, USA.
Oregon Health & Science University · USRush University Medical Center · USUniversity of Miami · USNational Institute on Aging · USUniversity of Ottawa · CAUniversity of Pennsylvania · US

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI QUINN, JOSEPH F · 1990 to 2019
$27.7M
Pilot CoreP30AG024978 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2004 to 2023
$9.0M
Resource CoreU2CAG054397 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2016 to 2019
$7.0M
Racial Differences in Late-Life Cognitive Decline and Risk of Alzheimer's DiseaseRF1AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2016 to 2019
$6.6M
Intra-Individual Dynamics of Stress and Health Among Informal Dementia CaregiversK01AG059839 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ANDERSON, LYNDSEY MEDORA · 2019 to 2022
$479k
NIA NIH HHS K01 AG059839NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG024978NIA NIH HHS P30 AG066518NIA NIH HHS RF1 AG022018NIA NIH HHS U2C AG054397
6 · The paper itself

Abstract

introductionFuture digital health research hinges on methodologies to conduct remote clinical assessments and in-home monitoring. The Collaborative Aging Research Using Technology (CART) initiative was introduced to establish a digital technology research platform that could widely assess activity in the homes of diverse cohorts of older adults and detect meaningful change longitudinally. This paper reports on the built end-to-end design of the CART platform, its functionality, and the resulting research capabilities.

methodsCART platform development followed a principled design process aiming for scalability, use case flexibility, longevity, and data privacy protection while allowing sharability. The platform, comprising ambient technology, wearables, and other sensors, was deployed in participants' homes to provide continuous, long-term (months to years), and ecologically valid data. Data gathered from CART homes were sent securely to a research server for analysis and future data sharing.

resultsThe CART system was created, iteratively tested, and deployed to 232 homes representing four diverse cohorts (African American, Latinx, low-income, and predominantly rural-residing veterans) of older adults (

conclusionThe CART initiative resulted in a minimally obtrusive digital health-enabled system that met the design principles while allowing for data capture over extended periods and can be widely used by the research community. The ability to monitor and manage health digitally within the homes of older adults is an important alternative to in-person assessments in many research contexts. Further advances will come with wider, shared use of the CART system in additional settings, within different disease contexts, and by diverse research teams.

Indexed as

AgingDigital biomarkersPervasive computingRemote monitoringSmart home

Identifiers

PMID33442584
PMCPMC7768162
OpenAlexW3109838872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.