ReviewDigital biomarkers2020
A Roadmap to Inform Development, Validation and Approval of Digital Mobility Outcomes: The Mobilise-D Approach.
Review in Digital biomarkers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Digital Endpoints for Assessing Instrumental Activities of Daily Living in Mild Cognitive Impairment: Systematic Review.Journal of medical Internet research · 2023Pooled it
- Listening to the patients' voice: a conceptual framework of the walking experience.Age and ageing · 2023Pooled it
- Trial
- Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy.Annals of neurology · 2025Trial
- Impact of Mobility Loss on Independence and Psychosocial Wellbeing in People With Parkinson's Disease and Carers: A Meta-Ethnography.Journal of geriatric psychiatry and neurology · 2026Review
- Meaningful digital mobility outcomes for people with Parkinson's disease: Insights grounded in diverse lived experience.Journal of Parkinson's disease · 2026Article
- Real-world walking and activity patterns in community-dwelling older adults: a cross-sectional analysis of baseline data from the SMART-AGE trial.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- A Digital Cueing Intervention for Parkinsonian Gait: Laboratory-Based Clinical Validation and Acute Gait Responses.Journal of medical systems · 2026Article
- Mobgap: A State-of-the-Art Python Framework for Reproducible Estimation and Algorithm Validation of Digital Mobility Outcomes from a Single Wearable Device.Sensors (Basel, Switzerland) · 2026Article
- Associations of insulin-like growth factor-1 with gait vigor, symmetry, and stability metrics measured by wearable sensors in older adults.BMC geriatrics · 2026Article
- Construct validity of real-world digital mobility outcomes in patients after proximal femoral fracture: a cross-sectional observational study.Scientific reports · 2026Observational
- The construct validity of real-world digital mobility outcomes in people with COPD.ERJ open research · 2026Article
- Neural Network-Based Granular Activity Recognition from Accelerometers: Assessing Generalizability Across Diverse Mobility Profiles.Sensors (Basel, Switzerland) · 2026Article
- Co-designing the future: End-user involvement in digital interventions.NPJ digital medicine · 2026Article
- WearGait-PD: An Open-Access Wearables Dataset for Gait in Parkinson's Disease and Age-Matched Controls.Scientific data · 2026Article
- Step count as a digital mobility outcome in orthopedics and orthopedic trauma surgery: a scoping review.EFORT open reviews · 2026Review
- Article
- Establishing global standards on wearable technology for measuring mobility in ageing populations: an international consensus exercise.Age and ageing · 2026Article
- Essential Tremor and Digital Biomarkers: A Scoping Review Using the TRACE Framework to Map Readiness for Clinical Trials and Routine Practice.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- The movement imperative: reimagining healthcare through the lens of human movement.Frontiers in sports and active living · 2026Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Health care has had to adapt rapidly to COVID-19, and this in turn has highlighted a pressing need for tools to facilitate remote visits and monitoring. Digital health technology, including body-worn devices, offers a solution using digital outcomes to measure and monitor disease status and provide outcomes meaningful to both patients and health care professionals. Remote monitoring of physical mobility is a prime example, because mobility is among the most advanced modalities that can be assessed digitally and remotely. Loss of mobility is also an important feature of many health conditions, providing a read-out of health as well as a target for intervention. Real-world, continuous digital measures of mobility (digital mobility outcomes or DMOs) provide an opportunity for novel insights into health care conditions complementing existing mobility measures. Accepted and approved DMOs are not yet widely available. The need for large collaborative efforts to tackle the critical steps to adoption is widely recognised. Mobilise-D is an example. It is a multidisciplinary consortium of 34 institutions from academia and industry funded through the European Innovative Medicines Initiative 2 Joint Undertaking. Members of Mobilise-D are collaborating to address the critical steps for DMOs to be adopted in clinical trials and ultimately health care. To achieve this, the consortium has developed a roadmap to inform the development, validation and approval of DMOs in Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease and recovery from proximal femoral fracture. Here we aim to describe the proposed approach and provide a high-level view of the ongoing and planned work of the Mobilise-D consortium. Ultimately, Mobilise-D aims to stimulate widespread adoption of DMOs through the provision of device agnostic software, standards and robust validation in order to bring digital outcomes from concept to use in clinical trials and health care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.