Evidence map›Paper›PMID 33442497›Full record

ArticleTranslational vision science & technology2020

Structure-Function Analysis in Macular Drusen With Mesopic and Scotopic Microperimetry.

Giovanni Montesano, Giovanni Ometto, Bethany E Higgins, Costanza Iester, Konstantinos Balaskas, Adnan Tufail, Usha Chakravarthy, Ruth E Hogg, David P Crabb

Open access · goldAbstract read
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In one paragraph

Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Giovanni MontesanoCity, University of London-Optometry and Visual Sciences, London, UK.
Giovanni OmettoCity, University of London-Optometry and Visual Sciences, London, UK.
Bethany E HigginsCity, University of London-Optometry and Visual Sciences, London, UK.
Costanza IesterCity, University of London-Optometry and Visual Sciences, London, UK.
Konstantinos BalaskasNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Adnan TufailNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Usha ChakravarthyCentre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
Ruth E HoggCentre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
David P CrabbCity, University of London-Optometry and Visual Sciences, London, UK.
City, University of London · GBMoorfields Eye Hospital NHS Foundation Trust · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Purpose: To investigate the structure-function relationship in eyes with drusen with mesopic and scotopic microperimetry. Methods: We analyzed structural and functional data from 43 eyes with drusen. Functional data were acquired with mesopic and scotopic two-color (red and cyan) microperimetry. Normative values were calculated using data from 56 healthy eyes. Structural measurements were green autofluorescence and dense macular optical coherence tomography scans. The latter were used to calculate the retinal pigment epithelium elevation (RPE-E) and the photoreceptor reflectivity ratio (PRR). The pointwise structure-function relationship was measured with linear mixed models having the log-transformed structural parameters as predictors and the sensitivity loss (SL, deviation from normal) as the response variable. Results: In the univariable analysis, the structural predictors were all significantly correlated ( Conclusions: Mesopic microperimetry shows better structure-function relationship compared to scotopic microperimetry; the relationship is weak, likely due to the early functional damage and the small number of tested locations affected by drusen. The relationship is stronger when locations with drusen are isolated for the mesopic and scotopic cyan test. Translational Relevance: These results could be useful to devise integrated structure-function methods to detect disease progression in intermediate age-related macular degeneration.

Indexed as

Macular DegenerationRetinal DrusenHumansRetinaTomography, Optical CoherenceVisual Field Testsage-related macular degenerationdrusenmicroperimetryoptical coherence tomographystructure–function

Identifiers

PMID33442497
PMCPMC7774115
OpenAlexW3115597889

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.