Evidence map›Paper›PMID 33442495›Full record

ArticleTranslational vision science & technology2020

Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility.

Sina Sharifi, Mohammad Mirazul Islam, Hannah Sharifi, Rakibul Islam, Per H Nilsson, Claes H Dohlman, Tom Eirik Mollnes, Eleftherios I Paschalis, James Chodosh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Sina SharifiDisruptive Technology Laboratory and Schepens Eye Research Institute, Massachusetts Eye and Ear; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Mohammad Mirazul IslamDisruptive Technology Laboratory and Schepens Eye Research Institute, Massachusetts Eye and Ear; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Hannah SharifiDisruptive Technology Laboratory and Schepens Eye Research Institute, Massachusetts Eye and Ear; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Rakibul IslamDepartment of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway.
Per H NilssonDepartment of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway.
Claes H DohlmanDisruptive Technology Laboratory and Schepens Eye Research Institute, Massachusetts Eye and Ear; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Tom Eirik MollnesDepartment of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway.
Eleftherios I PaschalisDisruptive Technology Laboratory and Schepens Eye Research Institute, Massachusetts Eye and Ear; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
James ChodoshDisruptive Technology Laboratory and Schepens Eye Research Institute, Massachusetts Eye and Ear; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Harvard University · USMassachusetts Eye and Ear Infirmary · USOslo University Hospital · NOSmith-Kettlewell Eye Research Institute · USUniversity of Oslo · NO

Funding

Generation of suturable artificial cornea from the integration of exfoliated graphene with gelatin glycidyl methacrylateK99EY030553 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI SHARIFI, SINA · 2020 to 2022
$242k
NEI NIH HHS K99 EY030553
6 · The paper itself

Abstract

Purpose: To evaluate titanium (Ti) sputtering of the poly(methyl methacrylate) (PMMA) stem of the Boston Keratoprosthesis (BK) as a method to enhance interfacial adhesion between the PMMA and the recipient corneal tissue. Methods: PMMA specimens were plasma treated with Ar/O Results: By contact angle studies, the Ti coating improved PMMA hydrophilicity to match that of medical-grade Ti (Ti-6Al-4V-ELI). Ti sputtering of contact surfaces resulted in a plate-like morphology with increased surface roughness, without impacting the transparency of the BK optical component. Scratch testing indicated that the mechanical behavior of the Ti coating was similar to that of casted Ti, and the coating was stable in pull-off adhesion testing. Sputtered Ti film was highly biocompatible based on tests of cell viability, adhesion, proliferation, differentiation, collagen deposition, and keratocan expression, the properties of which exceeded those of uncoated PMMA and did not induce increased complement activation. Conclusions: Titanium coating of the BK stem generated a mechanically and biologically favorable interface, which may help to enhance corneal stromal adhesion and biocompatibility. Translational Relevance: Improving the biocompatibility of the BK PMMA stem may improve long-term outcomes of implantation.

Indexed as

Polymethyl MethacrylateTitaniumCorneaHumansProstheses and ImplantsSurface PropertiesPolymethyl MethacrylateTitaniumartificial corneabiocompatibilityBoston Keratoprosthesispoly(methyl methacrylate) (PMMA)titanium sputtered coating

Identifiers

PMID33442495
PMCPMC7774111
OpenAlexW3115488857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.