Evidence map›Paper›PMID 33442068›Full record

ArticleIsrael journal of chemistry2020

Stereospecific Cross-Coupling Reactions Provide Conformationally-Biased Arylalkanes with Anti-Leukemia Activity.

Amberly B Sanford, Emily J Tollefson, Elizabeth R Jarvo

Abstract read
In one paragraph

Article in Israel journal of chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Harnessing C-O Bonds in Stereoselective Cross-Coupling and Cross-Electrophile Coupling Reactions.Synlett : accounts and rapid communications in synthetic organic chemistry · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amberly B SanfordDepartment of Chemistry, University of California, Irvine, Natural Sciences II, Irvine, CA, 92697.
Emily J TollefsonDepartment of Chemistry, University of California, Irvine, Natural Sciences II, Irvine, CA, 92697.
Elizabeth R JarvoDepartment of Chemistry, University of California, Irvine, Natural Sciences II, Irvine, CA, 92697.

Funding

Stereospecific Nickel-Catalyzed Cross-Coupling for Pharmacophore SynthesisR01GM100212 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI JARVO, ELIZABETH REINHARDT · 2012 to 2016
$1.4M
NIGMS NIH HHS R01 GM100212
6 · The paper itself

Abstract

A focused small library of carbamates and alcohols was prepared employing stereospecific Kumada-ring opening reactions of tetrahydropyrans. The core framework of the library members is acyclic and incorporates 1,3-substituents, to provide a conformational bias in avoiding syn-pentane interactions. A new compound with micromolar activity against MOLT-4, CCRF-CEM, and HL-60(TB) leukemia cell lines was identified from this series.

Indexed as

C–O couplingcross-couplingLeukemiaNickelsyn-pentane

Identifiers

PMID33442068
PMCPMC7799436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.