ArticleNature2021
Chaperone-mediated autophagy sustains haematopoietic stem-cell function.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers.
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186citing papers in PubMed
32.7field-weighted citation impact, top 1% of its field
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Who cites it
186 citing papers in PubMed, 269 citations in OpenAlex.
- Dietary Modulation of CMA: Implications for Cancer Prevention and Therapy.Physiology (Bethesda, Md.) · 2027Review
- Chaperone-mediated autophagy in physiological homeostasis, disease and ageing.Nature reviews. Molecular cell biology · 2026Review
- Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells.Nature aging · 2026Article
- Exploring the impact of nutrition and autophagy on infectious diseases to inform the development of homeostatic-nanomedicines for HIV-TB coinfections.Discover nano · 2026Review
- The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026Review
- Bone marrow-inspired DLL1-presenting microparticles enhance asymmetric division and maintenance of mouse hematopoietic stem and progenitor cells.Stem cell reports · 2026Article
- Hematopoietic Stem Cell Metabolism during Stress and Aging.Advances in geriatric medicine and research · 2026Article
- Impaired Chaperone-Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Autophagy in Melanoma: Molecular Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Chaperone-mediated autophagy is required for regulatory T cell function.Nature communications · 2026Article
- Mechanisms of TRIM21-mediated RUNX2 degradation via chaperone-mediated autophagy in periodontitis.Cell biology and toxicology · 2026Article
- Clinical translational research on stem cell products: prospects and challenges.Signal transduction and targeted therapy · 2026Review
- Lysosome-targeting live attenuated influenza vaccines elicit robust and broad immunity in mice.Nature communications · 2026Article
- Osteoarthritis: molecular pathogenesis and potential therapeutic options.Signal transduction and targeted therapy · 2026Review
- Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice.Nature communications · 2026Article
- Activation of a branched-chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness.Cell stem cell · 2026Article
- Chaperone-mediated autophagy sustains pericyte stemness necessary for brain tissue homeostasis.Journal of advanced research · 2026Article
- The unfolded protein response in progeria arteries originates from non-endothelial cell types.Life science alliance · 2026Article
- Hematopoietic (stem) cells-The elixir of life?FEBS letters · 2026Review
- Critical Roles and Molecular Mechanisms of Chaperone-Mediated Autophagy in Infections.International journal of molecular sciences · 2026Review
126 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 2 institutions in 1 country.
Shuxian DongDepartment of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4725-8482
Qian WangDepartment of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.
Yun-Ruei KaoDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Antonio DiazDepartment of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.
Inmaculada TassetDepartment of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.
Susmita KaushikDepartment of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-6096-5387
Victor ThiruthuvanathanDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Aliona ZintiridouDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Edward NievesDepartment of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Evripidis GavathiotisInstitute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-6319-8331
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-2258-6490
Britta WillInstitute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA. britta.will@einsteinmed.org.ORCID http://orcid.org/0000-0002-9534-6690
Ana Maria CuervoDepartment of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA. ana-maria.cuervo@einsteinmed.org.ORCID http://orcid.org/0000-0002-0771-700X
Albert Einstein College of Medicine · USUniversity of Colorado Anschutz Medical Campus · US
Funding
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2MRole of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SINGH, RAJAT · 2009 to 2024
$36.2MEinstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8MThe Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9MTraining in Aging ResearchT32AG023475 · NIA · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI NIR J BARZILAI, DEREK Major HUFFMAN · 2004 to 2026
$8.6MControl of vesicular trafficking in the hepatocyte.R01DK098408 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA, WOLKOFF, ALLAN W · 2013 to 2022
$5.6MThe role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4MDecreased Protein Degradation in AgingR37AG021904 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2013 to 2022
$4.4MIdentification and targeting of pathways separating healthy stem cell aging from malignant transformationR01CA230756 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Britta Will · 2018 to 2026
$4.0MDECREASED PROTEIN DEGRADATION IN AGINGR01AG021904 · NIA · YESHIVA UNIVERSITY · PI CUERVO, ANA MARIA · 2003 to 2012
$3.7MInteractions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6MTranscriptional regulation of hematopoietic stem cell fate during aging and bone marrow failureK01DK105134 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WILL, BRITTA · 2015 to 2019
$623kNCI NIH HHS P30 CA013330NCI NIH HHS R01 CA230756NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R21 HL150032NIA NIH HHS P01 AG031782NIA NIH HHS P30 AG038072NIA NIH HHS R01 AG021904NIA NIH HHS R37 AG021904NIA NIH HHS T32 AG023475NIDDK NIH HHS K01 DK105134NIDDK NIH HHS R01 DK098408NIH HHS AG023475NIH HHS CA330756NIH HHS DK105134
Abstract
The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-long production of blood cells
Indexed as
AdultAgedAgingAnimalsCells, CulturedCell Self RenewalChaperone-Mediated AutophagyEnergy MetabolismFemaleGlycolysisHematopoietic Stem CellsHumansLinoleic AcidMaleMiceMiddle AgedLinoleic Acid
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