Evidence map›Paper›PMID 33442061›Full record

ArticleNature2021

Functional refolding of the penetration protein on a non-enveloped virus.

Tobias Herrmann, Raúl Torres, Eric N Salgado, Cristina Berciu, Daniel Stoddard, Daniela Nicastro, Simon Jenni, Stephen C Harrison

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Mechanism of membrane perforation in rotavirus cell entry.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Virus Infection and mRNA Nuclear Export.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Tobias HerrmannDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Raúl TorresLaboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Eric N SalgadoLaboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Cristina BerciuRosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, Waltham, MA, USA.
Daniel StoddardRosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, Waltham, MA, USA.
Daniela NicastroRosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, Waltham, MA, USA.ORCID http://orcid.org/0000-0002-0122-7173
Simon JenniDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. jenni@crystal.harvard.edu.ORCID http://orcid.org/0000-0001-5722-5890
Stephen C HarrisonDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. harrison@crystal.harvard.edu.ORCID http://orcid.org/0000-0001-7215-9393
Boston Children's Hospital · USBrandeis University · USHarvard University · USMcLean Hospital · US

Funding

STRUCTURE AND ASSEMBLY OF VIRUSES AND OF COATED VESICLESR01CA013202 · NCI · HARVARD UNIVERSITY · PI HARRISON, STEPHEN COPLAN · 1985 to 2024
$4.9M
Structure and Assembly of VirusesR37CA013202 · NCI · CHILDREN'S HOSPITAL BOSTON · PI HARRISON, STEPHEN COPLAN · 2003 to 2012
$3.7M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA013202NCI NIH HHS R37 CA013202
6 · The paper itself

Abstract

A non-enveloped virus requires a membrane lesion to deliver its genome into a target cell

Indexed as

Cryoelectron MicroscopyProtein RefoldingVirus InternalizationAnimalsAntigens, ViralCapsid ProteinsCell LineCell MembraneDisulfidesModels, MolecularMutant ProteinsMutationProtein ConformationRNA-Binding ProteinsRotavirusViral Nonstructural ProteinsAntigens, ViralCapsid ProteinsDisulfidesMutant ProteinsNS35 protein, rotavirusnsp1 protein, RotavirusRNA-Binding ProteinsViral Nonstructural ProteinsVP4 protein, RotavirusVP7 protein, Rotavirus

Identifiers

PMID33442061
PMCPMC8297411
OpenAlexW3120227363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.