ArticleNature2021
Local immune response to food antigens drives meal-induced abdominal pain.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 3 pooled it
45.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 3 syntheses or guidelines pooled it, 291 citations in OpenAlex.
- Pooled it
- Randomised clinical trial and meta-analysis: mesalazine treatment in irritable bowel syndrome-effects on gastrointestinal symptoms and rectal biomarkers of immune activity.Alimentary pharmacology & therapeutics · 2022Pooled it
- The rationale for the treatment of long-Covid symptoms - A cardiologist's view.Frontiers in cardiovascular medicine · 2022Pooled it
- Acute effects of butyrate on intestinal permeability in patients with irritable bowel syndrome assessed by a novel colonoscopy research model.Gut microbes · 2025Trial
- COVID-19 Immunologic Antiviral Therapy With Omalizumab (CIAO)-a Randomized Controlled Clinical Trial.Open forum infectious diseases · 2024Trial
- Towards optimizing the host response to biotics: a report of an International Scientific Association for Probiotics and Prebiotics working group.Gut microbes · 2026Article
- Article
- Irritable bowel syndrome.Nature reviews. Disease primers · 2026Review
- Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.Allergy · 2026Review
- Irritable Bowel Syndrome and Allergic Diseases: A Nationwide Study of 1.5 Million Adolescents.Digestive diseases and sciences · 2026Article
- Associations of Meal-Related and Somatic Symptoms With Mucosal Eosinophil and Mast Cell Counts in Youth With Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Article
- Duloxetine as a gut-brain axis modulator in irritable bowel syndrome: neuroimmune, microbiota, and pharmacogenomic perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR-TKIs.Journal of clinical laboratory analysis · 2026Review
- Painful gastric glitch: an acute epigastric pain triggered by specific food as a new phenotype of postprandial epigastric pain syndrome.BMC gastroenterology · 2026Article
- Dietary Therapies for Gastrointestinal Disorders.Nutrients · 2026Review
- Synthetic food pigment sunset yellow potentiates food allergy via immune dysregulation and intestinal barrier dysfunction.NPJ science of food · 2026Article
- Fundamentals of Neurogastroenterology: Basic Science.Gastroenterology · 2026Review
- The Mast Cell-PAR2-TRP Axis: A Convergent Mechanism for Visceral Hypersensitivity Independent of Divergent Motility in IBS.Biomolecules · 2026Review
- Gut-Brain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia.International journal of molecular sciences · 2026Review
- The Gut Microbiota-Mast Cell Axis in Intestinal Homeostasis and Food Allergy Pathogenesis.Biomolecules · 2026Review
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
44 authors at 12 institutions in 6 countries.
Javier Aguilera-Lizarraga *Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8135-9933
Morgane V Florens *Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Maria Francesca ViolaLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.ORCID http://orcid.org/0000-0003-0660-9506
Piyush JainLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.ORCID http://orcid.org/0000-0002-3383-6299
Lisse DecraeckerLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Iris AppeltansLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Maria Cuende-EstevezLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Naomi FabreLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Kim Van BeekLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Eluisa PernaLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Dafne BalemansLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Nathalie StakenborgLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Stavroula TheofanousLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Goele BosmansLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Stéphanie U MondelaersLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Gianluca MatteoliLaboratory for Mucosal Immunology, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.ORCID http://orcid.org/0000-0002-2902-4976
Sales Ibiza MartínezLaboratory for Mucosal Immunology, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Cintya Lopez-LopezGastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.
Josue Jaramillo-PolancoGastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.ORCID http://orcid.org/0000-0002-4444-6149
Karel TalaveraLaboratory for Ion Channel Research, VIB Center for Brain and Disease Research, KU Leuven Department of Cellular and Molecular Medicine, Leuven, Belgium.ORCID http://orcid.org/0000-0002-3124-138X
Yeranddy A AlpizarNeuroscience Research group, BIOMED, Hasselt University, Hasselt, Belgium.
Thorsten B FeyerabendDivision of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.
Hans-Reimer RodewaldDivision of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.
Ricard FarreMucosal Permeability Lab, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.ORCID http://orcid.org/0000-0001-7158-171X
Frank A RedegeldDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
Jiyeon SiKU Leuven Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4356-5592
Jeroen RaesKU Leuven Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.ORCID http://orcid.org/0000-0002-1337-041X
Christine BreynaertAllergy and Clinical Immunology Research Group, KU Leuven Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.
Rik SchrijversAllergy and Clinical Immunology Research Group, KU Leuven Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.
Cédric BosteelsLaboratory of Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium.
Bart N LambrechtLaboratory of Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium.
Scott D BoydDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0963-044X
Ramona A HohDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Deirdre CabooterKU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.ORCID http://orcid.org/0000-0001-5502-5801
Maxim NelisKU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.
Patrick AugustijnsKU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.
Sven HendrixDepartment of Morphology, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Jessica StridDepartment of Immunology and Inflammation, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-3690-2201
Raf BisschopsLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
David E ReedGastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.
Stephen J VannerGastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.
Alexandre Denadai-SouzaLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.ORCID http://orcid.org/0000-0003-0385-1321
Mira M WoutersLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Guy E BoeckxstaensLaboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium. guy.boeckxstaens@kuleuven.be.ORCID http://orcid.org/0000-0001-8267-5797
KU Leuven · BEQueen's University · CAGerman Cancer Research Center · DEGhent University Hospital · BERega Institute for Medical Research · BEStanford University · USHasselt University · BEImperial College London · GBMSH Medical School Hamburg – University of Applied Sciences and Medical University · DEUniversity of Antwerp · BEUtrecht University · NLVIB-KU Leuven Center for Brain & Disease Research · BE
Funding
FUNCTIONAL ANALYSIS OF PATHOGENIC AND PROTECTIVE PEANUT ALLERGEN-SPECIFIC HUMAN ANTIBODIESR01AI125567 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2022
$2.6MUREASE AND GENE EXPRESSION OF HELICOBACTER PYLORIR01AI025567 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOBLEY, HARRY L. · 1989 to 2008
$2.2MEuropean Research Council 789384NIAID NIH HHS R01 AI025567NIAID NIH HHS R01 AI125567
Abstract
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal
Indexed as
Abdominal PainAdultAllergensAnimalsCitrobacter rodentiumDiarrheaEnterobacteriaceae InfectionsFemaleFoodFood HypersensitivityGlutensHumansImmunoglobulin EIntestinal MucosaIntestinesIrritable Bowel SyndromeAllergensGlutensImmunoglobulin EOvalbuminReceptors, Histamine H1Soybean Proteins
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.