Evidence map›Paper›PMID 33441982›Full record

ArticleMolecular psychiatry2021

Serotonin receptor 4 in the hippocampus modulates mood and anxiety.

Remzi Karayol, Lucian Medrihan, Jennifer L Warner-Schmidt, Ben W Fait, Meghana N Rao, Eva B Holzner, Paul Greengard, Nathaniel Heintz, Eric F Schmidt

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
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  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Novel, small molecules targeting the 5-HTbioRxiv : the preprint server for biology · 2025
    Article
  14. Impact of 5-HT4 Receptors on Neuron-Glial Network Activity In Vitro.International journal of molecular sciences · 2025
    Article
  15. Review
  16. Serotonergic Regulation in Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Remzi KarayolLaboratory of Molecular Biology, The Rockefeller University, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0003-3740-9611
Lucian MedrihanLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, 10065, USA.
Jennifer L Warner-SchmidtNeuroJenic Consulting LLC, Garden City, NY, 11530, USA.
Ben W FaitLaboratory of Molecular Biology, The Rockefeller University, New York, NY, 10065, USA.
Meghana N RaoLaboratory of Molecular Biology, The Rockefeller University, New York, NY, 10065, USA.
Eva B HolznerLaboratory of Molecular Biology, The Rockefeller University, New York, NY, 10065, USA.
Paul GreengardLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-4437-0893
Nathaniel HeintzLaboratory of Molecular Biology, The Rockefeller University, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-8874-8704
Eric F SchmidtLaboratory of Molecular Biology, The Rockefeller University, New York, NY, 10065, USA. eschmidt@rockefeller.edu.ORCID http://orcid.org/0000-0002-7869-0270
Rockefeller University · USHoward Hughes Medical Institute · US

Funding

RESEARCH SUPPORT CORE 4P30DA035756 · NIDA · ROCKEFELLER UNIVERSITY · PI HEINTZ, NATHANIEL · 2013 to 2017
$6.7M
Molecular phenotyping of cortical cell types in multiple rodent models of ALSR01NS091722 · NINDS · ROCKEFELLER UNIVERSITY · PI SCHMIDT, ERIC F · 2016 to 2020
$1.9M
Profiling axonal RNA in vivo using a viral TRAP approach.R21NS105047 · NINDS · ROCKEFELLER UNIVERSITY · PI SCHMIDT, ERIC F · 2018 to 2019
$466k
Howard Hughes Medical InstituteNIDA NIH HHS P30 DA035756NINDS NIH HHS R01 NS091722NINDS NIH HHS R21 NS105047
6 · The paper itself

Abstract

Serotonin receptor 4 (5-HT

Indexed as

AnxietyHippocampusAnimalsDentate GyrusMiceNeuronsReceptors, SerotoninReceptors, Serotonin, 5-HT4Receptors, SerotoninReceptors, Serotonin, 5-HT4

Identifiers

PMID33441982
PMCPMC8275670
OpenAlexW3118303561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.