ArticleScientific reports2021
Functional connectome differences in individuals with hallucinations across the psychosis continuum.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations.NeuroImage. Clinical · 2022Pooled it
- Effects of antipsychotic medication on functional connectivity in major depressive disorder with psychotic features.Molecular psychiatry · 2023Trial
- Network based statistics associates increased connectivity to REM sleep disorder and hallucinations in early DLB.NPJ Parkinson's disease · 2026Article
- A working model of neural activity and phenomenal experience in psychosis.Molecular psychiatry · 2024Review
- Altered resting-state functional connectivity in a thalamo-cortico-cerebellar network in patients with schizophrenia.Scientific reports · 2024Article
- Working memory and sensory memory in subclinical high schizotypy: An avenue for understanding schizophrenia?The European journal of neuroscience · 2023Review
- Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum.Schizophrenia bulletin · 2022Article
- Fragmented sleep relates to hallucinations across perceptual modalities in the general population.Scientific reports · 2021Article
- Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions.NeuroImage. Clinical · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
Abstract
Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P < 0.001 adjusted). Differential effects were observed for bipolar-I disorder patients with hallucinations versus controls, mainly characterized by decreased connectivity between fronto-temporal and fronto-striatal areas (P = 0.012 adjusted). No connectivity alterations were found between bipolar-I disorder patients without hallucinations and controls. Our results support the notion that hallucinations in non-clinical individuals and schizophrenia patients are related to altered interactions between sensory and higher-order cognitive brain regions. However, a different dysconnectivity pattern was observed for bipolar-I disorder patients with hallucinations, which implies a different neural mechanism across the psychosis continuum.
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