Evidence map›Paper›PMID 33441959›Full record

ArticleScientific reports2021

Odontogenesis-associated phosphoprotein truncation blocks ameloblast transition into maturation in Odaph

Tian Liang, Yuanyuan Hu, Kazuhiko Kawasaki, Hong Zhang, Chuhua Zhang, Thomas L Saunders, James P Simmer, Jan C-C Hu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Citrate Transporter NaCT and Enamel Mineralization: TheInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. A novelJournal of dental sciences · 2024
    Article
  8. Article
  9. Enamel defects in Acp4Scientific reports · 2022
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tian LiangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI, 48108, USA.
Yuanyuan HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI, 48108, USA.
Kazuhiko KawasakiDepartment of Anthropology, Pennsylvania State University, University Park, PA, 16802, USA.
Hong ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI, 48108, USA.
Chuhua ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI, 48108, USA.
Thomas L SaundersDepartment of Internal Medicine, Division of Molecular, Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
James P SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI, 48108, USA. jsimmer@umich.edu.
Jan C-C HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI, 48108, USA.
University of Michigan–Ann Arbor · USPennsylvania State University · US

Funding

DSPP Function, Pathophysiology, and Genetic DiagnosisR01DE027675 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMMER, JAMES P · 2018 to 2022
$2.4M
Development and Validation of Novel Amelogenesis ModelsUH3DE028849 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2021 to 2022
$621k
Development and Validation of Novel Amelogenesis ModelsUG3DE028849 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2019 to 2020
$619k
NIDCR NIH HHS R01DE027675NIDCR NIH HHS UG3 DE028849NIDCR NIH HHS UH3 DE028849
6 · The paper itself

Abstract

Mutations of Odontogenesis-Associated Phosphoprotein (ODAPH, OMIM *614829) cause autosomal recessive amelogenesis imperfecta, however, the function of ODAPH during amelogenesis is unknown. Here we characterized normal Odaph expression by in situ hybridization, generated Odaph truncation mice using CRISPR/Cas9 to replace the TGC codon encoding Cys41 into a TGA translation termination codon, and characterized and compared molar and incisor tooth formation in Odaph

Indexed as

AmelogenesisAmeloblastsAmelogenesis ImperfectaAnimalsDental EnamelExtracellular Matrix ProteinsGene Knock-In TechniquesIncisorIn Situ HybridizationMiceMolarOdontogenesisPhosphoproteinsExtracellular Matrix ProteinsOdaph protein, mousePhosphoproteins

Identifiers

PMID33441959
PMCPMC7807025
OpenAlexW3120573681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.