ArticleScientific reports2021
Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
- Eight-week dietary methionine restriction does not impair resistance exercise-induced mTORC1 signalling activation in rats.Biochemistry and biophysics reports · 2026Article
- Effects of Aging in Combination with High-Fat or Ketogenic Diet on Skeletal Muscle Atrophy Following Denervation in C57BL/6J Mice.Nutrients · 2026Article
- Article
- Dietary methionine depletion and hydrogen sulfide-producing genes in perivascular adipose tissue of male Wistar rats.Physiological reports · 2025Article
- Mechanisms Underlying Muscle-Related Diseases and Aging: Insights into Pathophysiology and Therapeutic Strategies.Muscles (Basel, Switzerland) · 2025Review
- Short-term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice.Physiological reports · 2025Article
- Voluntary Exercise-Induced Skeletal Muscle Responses in Young and Aged Mice on a High-Fat Diet.Cureus · 2025Article
- Physical activity of mice on dietary sulfur amino acid restriction is influenced by age of diet initiation and biological sex.Scientific reports · 2023Article
- Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction.GeroScience · 2023Article
- Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle.Nature communications · 2023Article
- Transcriptome analysis of the gene expression of MFrontiers in physiology · 2023Article
- Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA).Scientific reports · 2022Article
- Serum Levels of Acylcarnitines and Amino Acids Are Associated with Liberation from Organ Support in Patients with Septic Shock.Journal of clinical medicine · 2022Article
- Isolation and evaluation of quinoa (Current research in food science · 2022Article
- Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction.Frontiers in aging · 2022Article
- Skeletal muscle and fiber type-specific intramyocellular lipid accumulation in obese mice.Bosnian journal of basic medical sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methionine restriction (MR) has been shown to reduce the age-induced inflammation. We examined the effect of MR (0.17% methionine, 10% kCal fat) and MR + high fat diet (HFD) (0.17% methionine, 45% kCal fat) on body mass, food intake, glucose tolerance, resting energy expenditure, hind limb muscle mass, denervation-induced atrophy and overload-induced hypertrophy in young and old mice. In old mice, MR and MR + HFD induced a decrease in body mass. Muscle mass per body mass was lower in old compared to young mice. MR restored some of the HFD-induced reduction in muscle oxidative capacity. The denervation-induced atrophy of the m. gastrocnemius was larger in animals on MR than on a control diet, irrespective of age. Old mice on MR had larger hypertrophy of m. plantaris. Irrespective of age, MR and MR + HFD had better glucose tolerance compared to the other groups. Young and old mice on MR + HFD had a higher resting VO
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