Evidence map›Paper›PMID 33441933›Full record

ArticleScientific reports2021

Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa.

Jana Freff, Kathrin Schwarte, Lisa Bröker, Judith Bühlmeier, Isabelle Kraft, Dana Öztürk, Anke Hinney, Volker Arolt, Udo Dannlowski, Georg Romer and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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  8. Expression of CXCR4 on CD4Frontiers in psychiatry · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Jana FreffDepartment of Mental Health, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Kathrin SchwarteDepartment of Mental Health, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Lisa BrökerDepartment of Mental Health, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Judith BühlmeierDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Isabelle KraftDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Dana ÖztürkDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Anke HinneyDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Volker AroltDepartment of Mental Health, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Udo DannlowskiDepartment of Mental Health, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Georg RomerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Münster, 48149, Münster, Germany.
Bernhard T BauneDepartment of Mental Health, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Johannes HebebrandDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Manuel FöckerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Judith AlferinkDepartment of Mental Health, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. Judith.Alferink@ukmuenster.de.
University Hospital Münster · DEUniversity of Duisburg-Essen · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d

Indexed as

Body CompositionBody Mass IndexAdipose TissueAdolescentAnorexia NervosaAntigens, CD19B-Lymphocytes, RegulatoryB-Lymphocyte SubsetsFemaleHumansImmunologic MemoryImmunophenotypingLymphocyte CountAntigens, CD19CD19 molecule, human

Identifiers

PMID33441933
PMCPMC7806719
OpenAlexW3120966378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.