Evidence map›Paper›PMID 33441885›Full record

ArticleScientific reports2021

Increased infiltration of regulatory T cells in hepatocellular carcinoma of patients with hepatitis B virus pre-S2 mutant.

Chiao-Fang Teng, Tsai-Chung Li, Ting Wang, Da-Ching Liao, Yi-Hsuan Wen, Tzu-Hua Wu, John Wang, Han-Chieh Wu, Woei-Cherng Shyu, Ih-Jen Su and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Chiao-Fang TengGraduate Institute of Biomedical Sciences, China Medical University, No. 91, Hsueh-Shih Rd., Northern Dist., Taichung City, 404, Taiwan, ROC. chiaofangteng@gmail.com.ORCID 0000-0002-5218-0571
Tsai-Chung LiDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan, ROC.
Ting WangOrgan Transplantation Center, China Medical University Hospital, Taichung, Taiwan, ROC.
Da-Ching LiaoSchool of Pharmacy, China Medical University, Taichung, Taiwan, ROC.
Yi-Hsuan WenSchool of Pharmacy, China Medical University, Taichung, Taiwan, ROC.
Tzu-Hua WuOrgan Transplantation Center, China Medical University Hospital, Taichung, Taiwan, ROC.
John WangDepartment of Pathology, China Medical University Hospital, Taichung, Taiwan, ROC.
Han-Chieh WuNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan, ROC.
Woei-Cherng ShyuGraduate Institute of Biomedical Sciences, China Medical University, No. 91, Hsueh-Shih Rd., Northern Dist., Taichung City, 404, Taiwan, ROC.
Ih-Jen SuDepartment of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan, ROC.
Long-Bin JengOrgan Transplantation Center, China Medical University Hospital, Taichung, Taiwan, ROC. longbin.cmuh@gmail.com.ORCID 0000-0002-4588-2268
China Medical University · TWAsia University · TWNational Health Research Institutes · TWSouthern Taiwan University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a frequent and deadly human cancer worldwide that is intimately associated with chronic hepatitis B virus (HBV) infection. Pre-S2 mutant is a HBV oncoprotein that plays important roles in HCC development and is linked to poor prognosis in HCC patients. However, the profiles of tumor-infiltrating lymphocytes in HCC tissues of pre-S2 mutant-positive patients remain unknown. In this study, we performed fluorescent immunohistochemistry staining to detect the infiltration of 'anti-tumor' cytotoxic T lymphocytes (CTLs) and 'pro-tumor' regulatory T cells (Tregs) in pre-S2 mutant-positive and -negative HCC patients. We showed that pre-S2 mutant-positive patients had a significantly higher infiltration of CD4

Indexed as

AdultAgedCarcinoma, HepatocellularFemaleHepatitis BHepatitis B Surface AntigensHepatitis B virusHumansLiver NeoplasmsLymphocytes, Tumor-InfiltratingMaleMiddle AgedMutationProtein PrecursorsT-Lymphocytes, RegulatoryHepatitis B Surface Antigenspresurface protein 2, hepatitis B surface antigenProtein Precursors

Identifiers

PMID33441885
PMCPMC7807072
OpenAlexW3119830163

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.