Evidence map›Paper›PMID 33441546›Full record

ArticleTranslational psychiatry2021

Striatal dopamine synthesis capacity in autism spectrum disorder and its relation with social defeat: an [

Rik Schalbroeck, Floris H P van Velden, Lioe-Fee de Geus-Oei, Maqsood Yaqub, Therese van Amelsvoort, Jan Booij, Jean-Paul Selten

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Aberrant type 2 dopamine and mu-opioid receptor availability in autism spectrum disorder.European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rik SchalbroeckRivierduinen Institute for Mental Healthcare, Leiden, The Netherlands. rschalbroeck@gmail.com.ORCID http://orcid.org/0000-0002-9855-5797
Floris H P van VeldenSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-2859-2119
Lioe-Fee de Geus-OeiSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-1817-2743
Maqsood YaqubDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
Therese van AmelsvoortSchool for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Jan BooijDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location Academic Medical Center, Amsterdam, The Netherlands.
Jean-Paul SeltenRivierduinen Institute for Mental Healthcare, Leiden, The Netherlands.
Leiden University Medical Center · NLMaastricht University · NLAmsterdam UMC Location University of Amsterdam · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in dopamine signalling have been implied in autism spectrum disorder (ASD), and these could be associated with the risk of developing a psychotic disorder in ASD adults. Negative social experiences and feelings of social defeat might result in an increase in dopamine functioning. However, few studies examined dopamine functioning in vivo in ASD. Here we examine whether striatal dopamine synthesis capacity is increased in ASD and associated with social defeat. Forty-four unmedicated, non-psychotic adults diagnosed with ASD and 22 matched controls, aged 18-30 years, completed a dynamic 3,4-dihydroxy-6-[

Indexed as

Autism Spectrum DisorderDopamineAdultCorpus StriatumDihydroxyphenylalanineHumansPositron-Emission TomographyPositron Emission Tomography Computed TomographySocial DefeatDihydroxyphenylalanineDopamine

Identifiers

PMID33441546
PMCPMC7806928
OpenAlexW3121102546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.