ArticleNature communications2021
Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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Who cites it
58 citing papers in PubMed, 124 citations in OpenAlex.
- A randomized controlled trial of alpha phase-locked auditory stimulation to treat symptoms of sleep onset insomnia.Scientific reports · 2024Trial
- Cerebellar Transcranial Direct Current Stimulation in Spinocerebellar Ataxia Type 3: a Randomized, Double-Blind, Sham-Controlled Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Trial
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- Neurophysiological Basis of Tremor Disorders: Parkinson's Disease, Essential Tremor, Tremor in Dystonia, and Holmes Tremor.Seminars in neurology · 2026Review
- Transcranial Alternating Current Stimulation for Pain: Mixed Evidence and the Path to Precision Neuromodulation.Brain sciences · 2026Review
- Signal-based differentiation of essential and dystonic tremor.Frontiers in neurology · 2026Article
- Falling asleep follows a predictable bifurcation dynamic.Nature neuroscience · 2025Article
- Phenotypical Differentiation of Tremor Using Time Series Feature Extraction and Machine Learning.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Review
- Defining the Rhythm: Developing a New Method to Describe Tremor and Myoclonus.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Thermodynamic Biomarkers of Neuroinflammation: Nanothermometry, Energy-Stress Dynamics, and Predictive Entropy in Glial-Vascular Networks.International journal of molecular sciences · 2025Review
- Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies.Movement disorders clinical practice · 2025Review
- The cerebellum shapes motions by encoding motor frequencies with precision and cross-individual uniformity.Nature biomedical engineering · 2025Article
- Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation.Journal of neural engineering · 2025Article
- Heartbeat perception is causally linked to frontal delta oscillations.Communications biology · 2025Article
- Virtual brain twins for stimulation in epilepsy.Nature computational science · 2025Article
- Wakefulness can be distinguished from general anesthesia and sleep in flies using a massive library of univariate time series analyses.PLoS biology · 2025Article
- Feedback Control of Coupled Nonlinear Oscillators with Uncertain Parameters.Systems & control letters · 2025Article
- Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor.Brain : a journal of neurology · 2025Article
- Optogenetic Mapping of Rhythmic Phase-Dependent Excitability in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 3 countries.
Funding
Abstract
Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates the characteristic Gibbs distortion. We then used ecHT to show that the aberrant neural oscillation that hallmarks essential tremor (ET) syndrome, the most common adult movement disorder, can be transiently suppressed via transcranial electrical stimulation of the cerebellum phase-locked to the tremor. The tremor suppression is sustained shortly after the end of the stimulation and can be phenomenologically predicted. Finally, we use feature-based statistical-learning and neurophysiological-modelling to show that the suppression of ET is mechanistically attributed to a disruption of the temporal coherence of the aberrant oscillations in the olivocerebellar loop, thus establishing its causal role. The suppression of aberrant neural oscillation via phase-locked driven disruption of temporal coherence may in the future represent a powerful neuromodulatory strategy to treat brain disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.