ArticleNature communications2021
Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Motility Matters: Quantitative Analysis of Salmonella Swimming and Swarming.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Decoupling virulence from growth: a synthetic α-helical peptide suppressesMicrobiology spectrum · 2026Article
- Interbacterial AI-2 signaling orchestrates chemotaxis, attachment, and antimicrobial peptide resistance to promoteiScience · 2026Article
- ZnbioRxiv : the preprint server for biology · 2026Article
- Mucus-derived glycans are inhibitory signals for Salmonella Typhimurium SPI-1-mediated invasion.Cell reports · 2025Article
- Article
- A Methyl-Accepting Chemotaxis Protein MCP-5685 Associated with Indole Synthesis in Pantoea ananatis YJ76 Influences its Plant Growth-Promoting Potential and Adaptability to Stress Conditions.Current microbiology · 2025Article
- Article
- Pseudomonas aeruginosa breaches respiratory epithelia through goblet cell invasion in a microtissue model.Nature microbiology · 2024Article
- Antibacterial Ingredients and Modes of the Methanol-Phase Extract from the Fruit ofPlants (Basel, Switzerland) · 2024Article
- Article
- CheV enhances the virulence of Salmonella Enteritidis, and the Chev-deleted Salmonella vaccine provides immunity in mice.BMC veterinary research · 2024Article
- Transcriptional Profiling of the Effect ofAntibiotics (Basel, Switzerland) · 2023Article
- A versatile regulatory toolkit of arabinose-inducible artificial transcription factors for Enterobacteriaceae.Communications biology · 2023Article
- SPI-1 virulence gene expression modulates motility of Salmonella Typhimurium in a proton motive force- and adhesins-dependent manner.PLoS pathogens · 2023Article
- Bacterial chemotaxis in human diseases.Trends in microbiology · 2023Review
- Distinct Potentially Adaptive Accumulation of Truncation Mutations in Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi A.Microbiology spectrum · 2022Article
- Adaptive lifestyle of bacteria determines phage-bacteria interaction.Frontiers in microbiology · 2022Article
- Article
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16 authors.
Funding
Abstract
In the enteric pathogen Salmonella enterica serovar Typhimurium, invasion and motility are coordinated by the master regulator HilD, which induces expression of the type III secretion system 1 (T3SS1) and motility genes. Methyl-accepting chemotaxis proteins (MCPs) detect specific ligands and control the direction of the flagellar motor, promoting tumbling and changes in direction (if a repellent is detected) or smooth swimming (in the presence of an attractant). Here, we show that HilD induces smooth swimming by upregulating an uncharacterized MCP (McpC), and this is important for invasion of epithelial cells. Remarkably, in vitro assays show that McpC can suppress tumbling and increase smooth swimming in the absence of exogenous ligands. Expression of mcpC is repressed by the universal regulator H-NS, which can be displaced by HilD. Our results highlight the importance of smooth swimming for Salmonella Typhimurium invasiveness and indicate that McpC can act via a ligand-independent mechanism when incorporated into the chemotactic receptor array.
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