ArticlePediatrics2021
Six-Year Neurodevelopmental Outcomes for Children With Single-Ventricle Physiology.
Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Predictive Validity of Developmental Screening Questionnaires for Identifying Children With Later Cognitive or Educational Difficulties: A Systematic Review.Frontiers in pediatrics · 2021Pooled it
- Cortical structure alterations in toddlers with different severities of congenital heart disease: a cross-sectional study.European journal of pediatrics · 2026Article
- Associations between preoperative cerebral white matter microstructural changes and neurodevelopmental deficits in CHD infants: a diffusion tensor imaging study.Italian journal of pediatrics · 2025Article
- Physical Activity and Executive Functioning in Children and Adolescents with Congenital Heart Defects: A Scoping Review.Journal of cardiovascular development and disease · 2024Article
- Parental Impressions and Perspectives of Efficacy in Prenatal Counseling for Single Ventricle Congenital Heart Disease.Pediatric cardiology · 2024Article
- Research gaps in the neurodevelopmental assessment of children with complex congenital heart defects: a scoping review.Frontiers in pediatrics · 2024Article
- Predictors of Human Milk Feeding and Direct Breastfeeding for Infants with Single Ventricle Congenital Heart Disease: Machine Learning Analysis of the National Pediatric Cardiology Quality Improvement Collaborative Registry.The Journal of pediatrics · 2023Article
- Critical congenital heart disease beyond HLHS and TGA: neonatal brain injury and early neurodevelopment.Pediatric research · 2023Article
- Initial Counseling Prior to Palliation for Hypoplastic Left Heart Syndrome: 2021 vs 2011.Pediatric cardiology · 2023Article
- Article
- Rapid bilateral pulmonary artery banding: A developmentally based proposal for the management of neonates with hypoplastic left heart.JTCVS open · 2023Article
- Article
- Preoperative Care of Neonates With Congenital Heart Disease.Neonatal network : NN · 2022Article
- Screening and Evaluation of Neurodevelopmental Impairments in Infants Under 6 Months of Age with Congenital Heart Disease.Pediatric cardiology · 2022Observational
- Clinical factors associated with microstructural connectome related brain dysmaturation in term neonates with congenital heart disease.Frontiers in neuroscience · 2022Article
- The Current Status of Neuroprotection in Congenital Heart Disease.Children (Basel, Switzerland) · 2021Review
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Authors and funding
20 authors at 16 institutions in 2 countries.
Funding
Abstract
objectivesTo determine if neurodevelopmental deficits in children with single-ventricle physiology change with age and early developmental scores predict 6-year outcomes.
methodsIn the Single Ventricle Reconstruction Trial, Bayley Scales of Infant Development, Second Edition, were administered at 14 months of age, and parents completed the Behavior Assessment System for Children, Second Edition (BASC-2) annually from the ages of 2 to 6 years. Scores were classified as average, at risk, or impaired. We calculated sensitivities, specificities, and positive and negative predictive values of earlier tests on 6-year outcomes.
resultsOf 291 eligible participants, 244 (84%) completed the BASC-2 at 6 years; more Single Ventricle Reconstruction participants than expected on the basis of normative data scored at risk or impaired on the BASC-2 Adaptive Skills Index at that evaluation (28.7% vs 15.9%;
conclusionsMany children with hypoplastic left heart syndrome who have low adaptive skills at the age of 6 years will not be identified by screening at earlier ages. With our findings, we highlight the importance of serial evaluations for children with critical congenital heart disease throughout development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.