Evidence map›Paper›PMID 33441485›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Physiological role of the 3'IgH CBEs super-anchor in antibody class switching.

Xuefei Zhang, Hye Suk Yoon, Aimee M Chapdelaine-Williams, Nia Kyritsis, Frederick W Alt

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  7. Orientation Regulation of Class-switch Recombination in Human B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
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  9. Review
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  12. Contribution of the IGCR1 regulatory element and the 3'Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. DNA Damage Response and Repair in Adaptive Immunity.Frontiers in cell and developmental biology · 2022
    Review
  17. Article
  18. Review
  19. An insulator that regulates chromatin extrusion and class switch recombination.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xuefei ZhangHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115; xuefei.zhang@childrens.harvard.edu alt@enders.tch.harvard.edu.ORCID 0000-0002-1873-6679
Hye Suk YoonHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.
Aimee M Chapdelaine-WilliamsHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0001-9402-4326
Nia KyritsisHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.
Frederick W AltHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115; xuefei.zhang@childrens.harvard.edu alt@enders.tch.harvard.edu.
Boston Children's Hospital · US

Funding

Mechanisms that Regulate Antibody Class Switch Recombination and Somatic HypermutationR37AI077595 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Frederick W. Alt · 2019 to 2026
$4.6M
Molecular Mechanisms of Class Switch RecombinationR01AI077595 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI ALT, FREDERICK W. · 2009 to 2018
$4.3M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI077595NIAID NIH HHS R37 AI077595
6 · The paper itself

Abstract

IgH class switch recombination (CSR) replaces Cμ constant region (C

Indexed as

AnimalsAntibodiesB-LymphocytesCCCTC-Binding FactorChromatinGerm-Line MutationImmunoglobulin Class SwitchingImmunoglobulin Heavy ChainsMiceRegulatory Sequences, Nucleic AcidTranscription, GeneticAntibodiesCCCTC-Binding FactorChromatinCtcf protein, mouseImmunoglobulin Heavy Chains3'IgH CBEschromatin loop extrusionclass switch recombinationpromoter competition

Identifiers

PMID33441485
PMCPMC7826415
OpenAlexW3118295771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.