ArticleNeurology2021
Role of the Nucleus Basalis as a Key Network Node in Temporal Lobe Epilepsy.
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Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Autonomic Network Signatures of Interictal Cardiorespiratory Dysfunction in Patients With Temporal Lobe Epilepsy.Neurology · 2026Article
- Nucleus basalis functional connectivity aberrations in temporal lobe epilepsy and improvements after successful epilepsy surgery.Epilepsia · 2026Article
- Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy.Epilepsia · 2026Article
- Impact of disease duration and surgical intervention on arousal networks in temporal lobe epilepsy.Journal of neurosurgery · 2025Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations.Frontiers in aging neuroscience · 2024Review
- Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI.AJNR. American journal of neuroradiology · 2023Article
- Abnormal functional connectivity of the posterior hypothalamus and other arousal regions in surgical temporal lobe epilepsy.Journal of neurosurgery · 2023Article
- Arousal and salience network connectivity alterations in surgical temporal lobe epilepsy.Journal of neurosurgery · 2023Article
- Abnormal brain functional network dynamics in sleep-related hypermotor epilepsy.CNS neuroscience & therapeutics · 2023Article
- Focal impaired awareness seizures in a rodent model: A functional anatomy.Epilepsia open · 2022Article
- Correlation Between the Functional Connectivity of Basal Forebrain Subregions and Vigilance Dysfunction in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic-Clonic Seizure.Frontiers in psychiatry · 2022Article
- Regional and global resting-state functional MR connectivity in temporal lobe epilepsy: Results from the Epilepsy Connectome Project.Epilepsy & behavior : E&B · 2021Article
- Article
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Authors and funding
10 authors at 1 institution in 1 country.
Hernán F J GonzálezFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA. hfjgonzalez@gmail.com.ORCID 0000-0002-1831-2091
Saramati NarasimhanFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.ORCID 0000-0002-2965-2200
Graham W JohnsonFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.ORCID 0000-0002-9154-4315
Kristin E WillsFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.ORCID 0000-0002-2652-5679
Kevin F HaasFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.
Peter E KonradFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.
Catie ChangFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.ORCID 0000-0003-1541-9579
Victoria L MorganFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.ORCID 0000-0001-8263-2324
Mikail RubinovFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.
Dario J EnglotFrom the Departments of Biomedical Engineering (H.F.J.G., G.W.J., P.E.K., C.C., V.L.M., M.R., D.J.E.) and Electrical Engineering and Computer Science (C.C., V.L.M., M.R., D.J.E.), Vanderbilt University; Departments of Neurological Surgery (S.N., K.E.W., P.E.K., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), and Neurology (K.F.H.) and Vanderbilt University Institute of Imaging Science (H.F.J.G., S.N., G.W.J., K.E.W., C.C., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, TN; and Department of Psychology (M.R.), Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.ORCID 0000-0001-8373-690X
Janelia Research Campus · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3MPostdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0MMedical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8MRelating Vigilance to Connectivity and Neurocognition in Temporal Lobe EpilepsyR01NS112252 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2019 to 2023
$3.0MThe Role of Network Connectivity in Post-Surgical Seizure Recurrence in Temporal Lobe EpilepsyR01NS110130 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2018 to 2023
$2.5MMRI Connectivity Biomarkers of Treatment Response in Focal EpilepsyR01NS108445 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2019 to 2024
$2.5MComputer-Assited Functional NeurosurgeryR01NS095291 · NINDS · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M., DHAESE, PIERRE F. · 2015 to 2018
$2.4MTraining Program for Innovative Engineering Research in Surgery and InterventionT32EB021937 · NIBIB · VANDERBILT UNIVERSITY · PI Dario J Englot, Michael Ian Miga · 2016 to 2026
$2.3MMRI Structural and Functional Connectivity Changes in Temporal Lobe EpilepsyR01NS075270 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2012 to 2016
$1.7MMULTIMODAL MAPPING OF SUBCORTICAL AND CORTICAL FUNCTIONAL NETWORK DISTURBANCES IN FOCAL EPILEPSYR00NS097618 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2017 to 2019
$743kMultimodal analysis of interictal and ictal brain connectivity in temporal lobe epilepsyF31NS106735 · NINDS · VANDERBILT UNIVERSITY · PI GONZALEZ, HERNAN FRANCISCO JOSE · 2018 to 2020
$89kNIBIB NIH HHS T32 EB001628NIBIB NIH HHS T32 EB021937NICHD NIH HHS P50 HD103537NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NINDS NIH HHS F31 NS106735NINDS NIH HHS R00 NS097618NINDS NIH HHS R01 NS075270NINDS NIH HHS R01 NS095291NINDS NIH HHS R01 NS108445NINDS NIH HHS R01 NS110130NINDS NIH HHS R01 NS112252
Abstract
objectiveTo determine whether the nucleus basalis of Meynert (NBM) may be a key network structure of altered functional connectivity in temporal lobe epilepsy (TLE), we examined fMRI with network-based analyses.
methodsWe acquired resting-state fMRI in 40 adults with TLE and 40 matched healthy control participants. We calculated functional connectivity of NBM and used multiple complementary network-based analyses to explore the importance of NBM in TLE networks without biasing our results by our approach. We compared patients to controls and examined associations of network properties with disease metrics and neurocognitive testing.
resultsWe observed marked decreases in connectivity between NBM and the rest of the brain in patients with TLE (0.91 ± 0.88, mean ± SD) vs controls (1.96 ± 1.13,
conclusionsThese results suggest that while NBM is rarely studied in epilepsy, it may be one of the most perturbed network nodes in TLE, contributing to widespread neural effects in this disabling disorder.
Indexed as
AdolescentAdultAgedArousalBasal Nucleus of MeynertCognitionElectroencephalographyEpilepsy, Temporal LobeFemaleFunctional LateralityHumansLimbic SystemLogistic ModelsMagnetic Resonance ImagingMaleMiddle Aged
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