ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Evidence for Subcortical Plasticity after Paired Stimulation from a Wearable Device.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Six weeks of isometric resistance training led to evidence of corticospinal but not reticulospinal adaptation in previously untrained adult males.Experimental brain research · 2026Trial
- Resistance training tempo selectively modulates corticospinal and reticulospinal excitability in humans.The Journal of physiology · 2026Trial
- Neurophysiological and neuromuscular responses associated with the repeated bout effect following eccentric exercise in healthy adults: a systematic review and meta-analysis.European journal of applied physiology · 2026Review
- Involvement of the reticulospinal system in the control of locomotion.The Journal of physiology · 2026Article
- Novel evidence of age-related cortical and subcortical constraints in cross-education.GeroScience · 2026Article
- Age-related differences in corticospinal and reticulospinal adaptations to short-term strength training.European journal of applied physiology · 2026Article
- What Is the StartReact Effect?Acta physiologica (Oxford, England) · 2026Review
- Enhanced Reticulospinal Output in Subacute Spinal Cord Injury Patients with Spasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Corticospinal, reticulospinal and motoneuronal contributions to fatigability during a sustained contraction of the elbow flexors.Experimental physiology · 2026Article
- Reticulospinal and corticospinal responses in long-term strength-trained and untrained adults.European journal of applied physiology · 2025Article
- Differences in Hebbian stimulation effects between biceps and triceps brachii in humans.Journal of neurophysiology · 2025Article
- There Are No Differences in Startle Conditioned Cervicomedullary Motor Evoked Potentials Across Isometric, Concentric, and Eccentric Muscle Actions at the Same Absolute Force Output.The European journal of neuroscience · 2025Article
- Article
- An ANN models cortical-subcortical interaction during post-stroke recovery of finger dexterity.Journal of neural engineering · 2024Article
- Age-related changes in reticulospinal contributions to anticipatory postural adjustments between back extensors and abdominal muscles.Experimental physiology · 2024Article
- Article
- Pairing Transcranial Magnetic Stimulation and Loud Sounds Produces Plastic Changes in Motor Output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Use of the EXOPULSE Mollii for severe ataxia in an adult male 4 months after cardiac arrest.BMJ case reports · 2023Article
- Influence of coil orientation on corticospinal excitability of trunk muscles during postural and volitional tasks in healthy adults.Frontiers in human neuroscience · 2023Article
- Startling stimuli increase maximal motor unit discharge rate and rate of force development in humans.Journal of neurophysiology · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Existing non-invasive stimulation protocols can generate plasticity in the motor cortex and its corticospinal projections; techniques for inducing plasticity in subcortical circuits and alternative descending pathways such as the reticulospinal tract (RST) are less well developed. One possible approach developed by this laboratory pairs electrical muscle stimulation with auditory clicks, using a wearable device to deliver stimuli during normal daily activities. In this study, we applied a variety of electrophysiological assessments to male and female healthy human volunteers during a morning and evening laboratory visit. In the intervening time (∼6 h), subjects wore the stimulation device, receiving three different protocols, in which clicks and stimulation of the biceps muscle were paired at either low or high rate, or delivered at random. Paired stimulation: (1) increased the extent of reaction time shortening by a loud sound (the StartReact effect); (2) decreased the suppression of responses to transcranial magnetic brain stimulation (TMS) following a loud sound; (3) enhanced muscle responses elicited by a TMS coil oriented to induce anterior-posterior (AP) current, but not posterior-anterior (PA) current, in the brain. These measurements have all been suggested to be sensitive to subcortical, possibly reticulospinal, activity. Changes were similar for either of the two paired stimulus rates tested, but absent after unpaired (control) stimulation. Taken together, these results suggest that pairing clicks and muscle stimulation for long periods does indeed induce plasticity in subcortical systems such as the RST.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.