Evidence map›Paper›PMID 33441395›Full record

ArticleJournal of clinical microbiology2021

Correlation of SARS-CoV-2 Nucleocapsid Antigen and RNA Concentrations in Nasopharyngeal Samples from Children and Adults Using an Ultrasensitive and Quantitative Antigen Assay.

Nira R Pollock, Timothy J Savage, Hanna Wardell, Rose A Lee, Anu Mathew, Martin Stengelin, George B Sigal

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 7 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 7 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  3. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection.The Cochrane database of systematic reviews · 2022
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  19. The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nira R PollockDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, USA nira.pollock@childrens.harvard.edu.ORCID 0000-0002-6396-2915
Timothy J Savage *Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
Hanna Wardell *Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
Rose A LeeDivision of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
Anu MathewMeso Scale Diagnostics, LLC., Rockville, Maryland, USA.
Martin StengelinMeso Scale Diagnostics, LLC., Rockville, Maryland, USA.
George B SigalMeso Scale Diagnostics, LLC., Rockville, Maryland, USA.
Boston Children's Hospital · USMeso Scale Discovery (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosis of COVID-19 by PCR offers high sensitivity, but the utility of detecting samples with high cycle threshold (

Indexed as

COVID-19SARS-CoV-2AdultAntigens, ViralChildDiagnostic Tests, RoutineHumansNucleocapsidRNASensitivity and SpecificityAntigens, ViralRNAantigenCOVID-19diagnosticnucleoproteinSARS-CoV-2

Identifiers

PMID33441395
PMCPMC8092747
OpenAlexW3119901770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.