Evidence map›Paper›PMID 33441369›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2021

Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal

Yukitoshi Izumi, Steven J Mennerick, James J Doherty, Charles F Zorumski

Open access · hybridAbstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
  2. Article
  3. Oxysterols in Central and Peripheral Synaptic Communication.Advances in experimental medicine and biology · 2024
    Article
  4. Article
  5. Article
  6. A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yukitoshi IzumiDepartment of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (Y.I., S.J.M., C.F.Z.); and Sage Therapeutics, Cambridge, Massachusetts (J.J.D.).ORCID 0000-0002-5596-1031
Steven J MennerickDepartment of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (Y.I., S.J.M., C.F.Z.); and Sage Therapeutics, Cambridge, Massachusetts (J.J.D.).
James J DohertyDepartment of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (Y.I., S.J.M., C.F.Z.); and Sage Therapeutics, Cambridge, Massachusetts (J.J.D.).
Charles F ZorumskiDepartment of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (Y.I., S.J.M., C.F.Z.); and Sage Therapeutics, Cambridge, Massachusetts (J.J.D.) zorumskc@wustl.edu.
Innovative Clinical Research · USOphthalmology Consultants · US

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI COVEY, DOUGLAS F · 2021 to 2025
$12.2M
Oxysterols and NMDAR FunctionR01MH101874 · NIMH · WASHINGTON UNIVERSITY · PI MENNERICK, STEVEN J, ZORUMSKI, CHARLES F · 2014 to 2018
$1.9M
Chemogenetic analysis of ethanol's selectivity for GABAA receptor populationsR21AA026753 · NIAAA · WASHINGTON UNIVERSITY · PI MENNERICK, STEVEN J · 2019 to 2020
$410k
NEUROSTEROIDS & PROXIMAL INHIBITION IN THE HIPPOCAMPUSR21MH114866 · NIMH · WASHINGTON UNIVERSITY · PI ZORUMSKI, CHARLES F · 2018 to 2018
$234k
NIAAA NIH HHS R21 AA026753NIMH NIH HHS P50 MH122379NIMH NIH HHS R01 MH101874NIMH NIH HHS R21 MH114866
6 · The paper itself

Abstract

Ethanol is a noncompetitive inhibitor of

Indexed as

LearningLong-Term PotentiationAnimalsCentral Nervous System DepressantsDrug InteractionsEthanolHippocampusMaleOxysterolsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateCentral Nervous System DepressantsEthanolOxysterolsReceptors, N-Methyl-D-Aspartate

Identifiers

PMID33441369
PMCPMC8051516
OpenAlexW3120467122

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.