Evidence map›Paper›PMID 33441342›Full record

ArticleJournal of virology2021

A Potent anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germline Immunoglobulin Gene Polymorphism in Rhesus Macaques.

Saori Matsuoka, Takeo Kuwata, Hiroshi Ishii, Tsuyoshi Sekizuka, Makoto Kuroda, Masato Sano, Midori Okazaki, Hiroyuki Yamamoto, Mikiko Shimizu, Shuzo Matsushita and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Saori MatsuokaAIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Takeo KuwataJoint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan tkuwata@kumamoto-u.ac.jp tmatano@nih.go.jp.
Hiroshi IshiiAIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Tsuyoshi SekizukaPathogen Genomics Center, National Institute of Infectious Disease, Tokyo, Japan.
Makoto KurodaPathogen Genomics Center, National Institute of Infectious Disease, Tokyo, Japan.
Masato SanoAIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Midori OkazakiAIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Hiroyuki YamamotoAIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Mikiko ShimizuJoint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Shuzo MatsushitaJoint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Yohei SekiPrimate Research Institute, Kyoto University, Inuyama, Japan.
Akatsuki SaitoPrimate Research Institute, Kyoto University, Inuyama, Japan.
Hiromi SakawakiInstitute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Vanessa M HirschLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-1228-7761
Tomoyuki MiuraInstitute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Hirofumi AkariPrimate Research Institute, Kyoto University, Inuyama, Japan.ORCID https://orcid.org/0000-0003-2166-6015
Tetsuro MatanoAIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan tkuwata@kumamoto-u.ac.jp tmatano@nih.go.jp.ORCID https://orcid.org/0000-0003-3096-6749
National Institute of Infectious Diseases · JPKyoto University · JPKumamoto University · JPNational Institutes of Health · US

Funding

Pathogenesis Studies Of Simian Immunodeficiency Virus Infection Of MonkeysZIAAI000370 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HIRSCH, VANESSA M. · 2009 to 2022
$16.2M
6 · The paper itself

Abstract

Virus infection induces B cells with a wide variety of B cell receptor (BCR) repertoires. Patterns of induced BCR repertoires are different in individuals, while the underlying mechanism causing this difference remains largely unclear. In particular, the impact of germ line BCR immunoglobulin (Ig) gene polymorphism on B cell/antibody induction has not fully been determined. In the present study, we found a potent antibody induction associated with a germ line BCR Ig gene polymorphism. B404-class antibodies, which were previously reported as potent anti-simian immunodeficiency virus (SIV) neutralizing antibodies using the germ line VH3.33 gene-derived Ig heavy chain, were induced in five of 10 rhesus macaques after SIVsmH635FC infection. Investigation of VH3.33 genes in B404-class antibody inducers (

Identifiers

PMID33441342
PMCPMC8092685
OpenAlexW3119950506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.