Evidence map›Paper›PMID 33441249›Full record

ReviewDental materials : official publication of the Academy of Dental Materials2021

Fighting viruses with materials science: Prospects for antivirus surfaces, drug delivery systems and artificial intelligence.

Vinicius Rosa, Dean Ho, Robinson Sabino-Silva, Walter L Siqueira, Nikolaos Silikas

Abstract readReview
In one paragraph

Review in Dental materials : official publication of the Academy of Dental Materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Passive antifouling and active self-disinfecting antiviral surfaces.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vinicius RosaFaculty of Dentistry, National University of Singapore, Singapore; Craniofacial Research and Innovation Center, National University of Singapore, Singapore. Electronic address: denvr@nus.sg.
Dean HoThe N.1 Institute for Health (N.1), Institute for Digital Medicine (WisDM), Department of Biomedical Engineering, and Department of Pharmacology, National University of Singapore, Singapore. Electronic address: biehead@nus.edu.sg.
Robinson Sabino-SilvaDepartment of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Brazil. Electronic address: robinsonsabino@gmail.com.
Walter L SiqueiraCollege of Dentistry, University of Saskatchewan, Canada. Electronic address: walter.siqueira@usask.ca.
Nikolaos SilikasDivision of Dentistry, School of Medical Sciences, University of Manchester, United Kingdom. Electronic address: nikolaos.silikas@manchester.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveViruses on environmental surfaces, in saliva and other body fluids represent risk of contamination for general population and healthcare professionals. The development of vaccines and medicines is costly and time consuming. Thus, the development of novel materials and technologies to decrease viral availability, viability, infectivity, and to improve therapeutic outcomes can positively impact the prevention and treatment of viral diseases.

methodsHerein, we discuss (a) interaction mechanisms between viruses and materials, (b) novel strategies to develop materials with antiviral properties and oral antiviral delivery systems, and (c) the potential of artificial intelligence to design and optimize preventive measures and therapeutic regimen.

resultsThe mechanisms of viral adsorption on surfaces are well characterized but no major breakthrough has become clinically available. Materials with fine-tuned physical and chemical properties have the potential to compromise viral availability and stability. Emerging strategies using oral antiviral delivery systems and artificial intelligence can decrease infectivity and improve antiviral therapies. SIGNIFICANCE: Emerging viral infections are concerning due to risk of mortality, as well as psychological and economic impacts. Materials science emerges for the development of novel materials and technologies to diminish viral availability, infectivity, and to enable enhanced preventive and therapeutic strategies, for the safety and well-being of humankind.

Indexed as

Artificial IntelligenceCOVID-19Antiviral AgentsDrug Delivery SystemsHumansMaterials ScienceAntiviral AgentsCoatingCoronavirusCOVID-19DiagnosticInfectionNanomaterialNanotechnologyPandemicSalivaVaccine

Identifiers

PMID33441249
PMCPMC7834288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.