Evidence map›Paper›PMID 33441158›Full record

Trial reportJournal of the International Society of Sports Nutrition2021

The effect of Omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage.

Yvoni Kyriakidou, Carly Wood, Chrystalla Ferrier, Alberto Dolci, Bradley Elliott

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Effects of LCNutrients · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yvoni KyriakidouTranslational Physiology Research Group, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, W1W 6UW, UK.
Carly WoodTranslational Physiology Research Group, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, W1W 6UW, UK.
Chrystalla FerrierTranslational Physiology Research Group, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, W1W 6UW, UK.
Alberto DolciTranslational Physiology Research Group, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, W1W 6UW, UK.
Bradley ElliottTranslational Physiology Research Group, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, W1W 6UW, UK. b.elliott@westminster.ac.uk.ORCID http://orcid.org/0000-0003-4295-3785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise-induced muscle damage (EIMD) results in transient muscle inflammation, strength loss, muscle soreness and may cause subsequent exercise avoidance. Omega-3 (n-3) supplementation may minimise EIMD via its anti-inflammatory properties, however, its efficacy remains unclear.

methodsHealthy males (n = 14, 25.07 ± 4.05 years) were randomised to 3 g/day n-3 supplementation (N-3, n = 7) or placebo (PLA, n = 7). Following 4 weeks supplementation, a downhill running protocol (60 min, 65% V̇O

resultsMuscle soreness was significantly lower in N-3 vs PLA group at 24 h post-EIMD (p = 0.034). IL-6 was increased in PLA (p = 0.009) but not in N-3 (p = 0.434) following EIMD, however, no significant differences were noted between groups. Peak power was significantly suppressed in PLA relative to pre-EIMD but not in N-3 group at 24 h post-EIMD. However, no significant difference in peak power output was observed between groups. MVIC, CK and TNF-α were altered by EIMD but did not differ between groups.

conclusionN-3 supplementation for 4 weeks may successfully attenuate minor aspects of EIMD. Whilst not improving performance, these findings may have relevance to soreness-associated exercise avoidance.

Indexed as

ExerciseAdultAnalysis of VarianceBiomarkersCreatine KinaseFatty Acids, Omega-3HumansInterleukin-6Isometric ContractionMaleMuscle, SkeletalMuscle StrengthMuscle WeaknessMuscular DiseasesMyalgiaMyositisBiomarkersCreatine KinaseFatty Acids, Omega-3Interleukin-6Tumor Necrosis Factor-alphaDOMSEccentric exerciseEIMDErgogenic aidInflammationMuscle damageOmega-3PerformanceRecoverySupplementation

Identifiers

PMID33441158
PMCPMC7807509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.