ArticleOrphanet journal of rare diseases2021
Correlation of retinal and choroidal microvascular impairment in systemic sclerosis.
Article in Orphanet journal of rare diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Microvascular markers in systemic sclerosis: a comparative OCT-angiography and nailfold videocapillaroscopy study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Optical Coherence Tomography Angiography in Patients with Mixed Connective Tissue Disease.Biomedicines · 2026Article
- Retinal and choroidal microvascular alterations in ıdiopathic pulmonary fibrosis: an OCTA study.International ophthalmology · 2026Article
- Systemic sclerosis: Correlations of OCTA, capillaroscopy and elastography in microvascular assessment.Irish journal of medical science · 2026Article
- Anterior segment oculomics in systemic sclerosis: reduced OCT-derived pupil diameter without iris morphology alterations.Frontiers in medicine · 2026Article
- Ophthalmic Posterior Segment OCTA Metrics as Potential Biomarkers for Systemic Involvement in Systemic Sclerosis, Systemic Lupus Erythematosus, and Behçet Disease: A Systematic Review.Open access rheumatology : research and reviews · 2025Review
- Ocular Manifestation in Systemic Sclerosis-A Literature Review.Life (Basel, Switzerland) · 2024Review
- Retinal Vascular Abnormalities and Clinical Parameters in Systemic Sclerosis.Journal of clinical medicine · 2024Article
- Macular choroidal thickness, volume, and vascularity index in patients with systemic sclerosis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Peripheral and ocular microvascular alterations in systemic sclerosis: observations from capillaroscopic assessments, perfusion peripheral analysis, and optical coherence tomography angiography.Rheumatology international · 2024Article
- Paracentral acute middle maculopathy in systemic sclerosis and subsequent branch retinal artery occlusion.American journal of ophthalmology case reports · 2023Article
- Involvement of the systemic microcirculation in pediatric uveitis.Pediatric rheumatology online journal · 2023Article
- Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approach.International journal of ophthalmology · 2023Article
- Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis.Frontiers in medicine · 2023Article
- The Function of Retinal Thickness and Microvascular Alterations in the Diagnosis of Systemic Sclerosis.BioMed research international · 2023Article
- Retinal microvasculature alteration in patients with systemic sclerosis and chloroquine treatment.Quantitative imaging in medicine and surgery · 2022Article
- Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography.Scientific reports · 2022Article
- Detection of microvascular changes in systemic sclerosis and other rheumatic diseases.Nature reviews. Rheumatology · 2021Review
- Evaluating Retinal and Choroidal Perfusion Changes after Isometric and Dynamic Activity Using Optical Coherence Tomography Angiography.Diagnostics (Basel, Switzerland) · 2021Article
- Extrapulmonary manifestations of pulmonary arterial hypertension.Expert review of respiratory medicineReview
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Authors and funding
5 authors.
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Abstract
purposeTo investigate the correlation between retinal and choroidal microperfusion in patients with systemic sclerosis (SSc) using optical coherence tomography angiography (OCTA).
methodsIn this cross-sectional study SSc patients without clinical evidence of ocular involvement and healthy, age- and sex-matched volunteers were recruited. Participants underwent specific rheumatological and ophthalmological examinations, including optical coherence tomography (OCT) and OCTA. Retinal and choroidal thicknesses as well as perfusion of the retina and the choroidal sublayers were evaluated.
resultsA total of 15 SSc patients (30 eyes) with a median disease duration of 60 months and 15 matched, healthy controls (30 eyes) were recruited. OCT data revealed a significantly lower macular volume, as well as Sattler's layer and Haller's layer thickness in SSc patients compared to controls. In OCTA analysis, the perfusion of both retinal plexus as well as Sattler's and Haller's layer were significantly reduced in the SSc group. Patients with a disease duration of more than 60 months showed a statistically significant positive correlation between retinal and choroidal malperfusion, while those with a shorter disease duration did not.
conclusionOCTA analysis confirmed impairment of retinal and choroidal microperfusion in SSc patients, supporting the hypothesis of wide spreading vascular injury. In early stages, either the retinal or the choroidal perfusion seems to be involved, while later on, vascular impairment affects both tissues alike. Both, retinal and choroidal examinations should be considered as soon as the diagnosis of SSc is made, to avoid missing out on early alterations.
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