Evidence map›Paper›PMID 33441114›Full record

ArticleBMC complementary medicine and therapies2021

Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development.

Lubov V Krepkova, Valentina V Bortnikova, Aleksandra N Babenko, Praskovya G Mizina, Vladimir A Mkhitarov, Kathleen M Job, Catherine M Sherwin, Elena Y Enioutina

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Article in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lubov V KrepkovaCenter of Medicine, All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina Street 7, Moscow, 117216, Russia.
Valentina V BortnikovaCenter of Medicine, All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina Street 7, Moscow, 117216, Russia.
Aleksandra N BabenkoCenter of Medicine, All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina Street 7, Moscow, 117216, Russia.
Praskovya G MizinaCenter of Medicine, All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina Street 7, Moscow, 117216, Russia.
Vladimir A MkhitarovFSBI "Research Institute of Human Morphology", 3 Tsyurupy St., Moscow, 117418, Russia.
Kathleen M JobDivision of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, 295 Chipeta Way, Salt Lake City, UT, 84108, USA.
Catherine M SherwinDepartment of Pediatrics, Wright State University, Boonshoft School of Medicine, Dayton Children's Hospital, Children's Plaza, Dayton, OH, 45404, USA.
Elena Y EnioutinaDivision of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, 295 Chipeta Way, Salt Lake City, UT, 84108, USA. elena.enioutina@hsc.utah.edu.ORCID http://orcid.org/0000-0003-3738-1460

Funding

FSBIU VILAR 0576-2019-0009
6 · The paper itself

Abstract

backgroundThe dysfunction of the thyroid gland is a common medical condition. Nowadays, patients frequently use medicinal herbs as complementary or alternative options to conventional drug treatments. These patients may benefit from treatment of thyroid dysfunctions with Potentilla alba L. preparations. While it has been reported that Potentilla alba preparations have low toxicity, nothing is known about their ability to affect reproductive functions in patients of childbearing age.

methodsMale Wistar rats were orally treated with a thyrotrophic botanical drug, standardized Potentilla alba Dry Extract (PADE), at doses 8 and 40 times higher than the median therapeutic dose recommended for the clinical trials, for 60 consecutive days. Male Wistar rats receiving water (H

resultsHerein, we report that oral treatment of male Wistar rats with PADE before mating with intact females instigated marked effects on male reproductive organs. Treatment significantly decreased the motility of the sperm and increased the number of pathological forms of spermatozoa. Additionally, a dose-dependent effect on Leydig cells was observed. However, these PADE effects did not significantly affect male fertility nor fetal and offspring development when PADE-treated males were mated with intact females.

conclusionsPADE treatment of male rates negatively affected sperm and testicular Leydig cell morphology. However, these changes did not affect male fertility and offspring development. It is currently not known whether PADE treatment may affect human male fertility and offspring development. Therefore, these results from an animal study need to be confirmed in humans. Results from this animal study can be used to model the exposure-response relationship and adverse outcomes in humans.

Indexed as

AnimalsFemaleFertilityFetal DevelopmentGenitalia, MaleMalePlant ExtractsPotentillaRatsRats, WistarSpermatozoaThyroid DiseasesWeight GainPlant ExtractsHerbal drug toxicityMale reproductive healthPotentilla albaPreclinical drug evaluation

Identifiers

PMID33441114
PMCPMC7807504

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