Evidence map›Paper›PMID 33441102›Full record

Observational studyBMC geriatrics2021

The effect of cognitive dysfunction on mid- and long-term mortality after vascular surgery.

András Szabó, Krisztina Tóth, Ádám Nagy, Dominika Domokos, Nikoletta Czobor, Csaba Eke, Ágnes Sándor, Béla Merkely, Éva Susánszky, János Gál and 1 more

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02224222 (Assessment of Frailty as a Risk Factor for Cardiac and Vascular Surgery), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02224222 unknown statusnot on this map

Assessment of Frailty as a Risk Factor for Cardiac and Vascular Surgery

Typeobservational_patient_registrySponsorSemmelweis University Heart and Vascular CenterRan2014 to 2020Enrolled300ConditionsIntellectual Frailty of Aging, Cardiovascular Diseases, Myocardial Infarction, Vascular Diseases
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

András SzabóDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 78 Üllői st., Budapest, H-1082, Hungary. andraas.szaboo@gmail.com.ORCID 0000-0003-0311-5033
Krisztina TóthKároly Rácz School of PhD Studies, Semmelweis University, Budapest, Hungary.
Ádám NagyKároly Rácz School of PhD Studies, Semmelweis University, Budapest, Hungary.
Dominika DomokosHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Nikoletta CzoborDepartment of Anesthesiology and Intensive Care, Medical Centre of Hungarian Defense Forces, Budapest, Hungary.
Csaba EkeKároly Rácz School of PhD Studies, Semmelweis University, Budapest, Hungary.
Ágnes SándorDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 78 Üllői st., Budapest, H-1082, Hungary.
Béla MerkelyHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Éva SusánszkyInstitute of Behavioural Science, Semmelweis University, Budapest, Hungary.
János GálDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 78 Üllői st., Budapest, H-1082, Hungary.
Andrea SzékelyDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 78 Üllői st., Budapest, H-1082, Hungary.
Semmelweis University · HUZrínyi Miklós National Defence University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent decades, previous studies have noted the importance of frailty, which is a frequently used term in perioperative risk evaluations. Psychological and socioeconomical domains were investigated as part of frailty syndrome. The aim of this study was to assess the importance of these factors in mortality after vascular surgery.

methodsIn our prospective, observational study (ClinicalTrials.gov Identifier: NCT02224222), we examined 164 patients who underwent elective vascular surgery between 2014 and 2017. At the outpatient anaesthesiology clinic, patients completed a questionnaire about cognitive functions, depression and anxiety, social support and self-reported quality of life were assessed using a comprehensive frailty index, in addition to medical variables. Propensity score matching was performed to analyse the difference between patients and controls in a nationwide population cohort. The primary outcome was 4 year mortality. The Kaplan-Meier method and Cox regression analysis were used for statistical analyses.

resultsThe patients' mean age was 67.05 years (SD: 9.49 years). Mini-Mental State Examination scores of less than 27 points were recorded for 41 patients. Overall mortality rates were 22.4 and 47.6% in the control and cognitive impairment groups, respectively (p = 0.013). In the univariate Cox regression analysis, cognitive impairment measured using age- and education-adjusted MMSE scores increased the risk of mortality (AHR: 2.842, 95% CI: 1.389-5.815, p = 0.004).

conclusionEven mild cognitive dysfunction measured preoperatively using the MMSE represents a potentially important risk factor for mortality after vascular surgery.

Indexed as

Cognitive DysfunctionFrail ElderlyAgedHumansMental Status and Dementia TestsProspective StudiesQuality of LifeRisk FactorsCognitive dysfunctionMini mental state examinationPerioperative risk factorsPsychosocial factorsSocial supportVascular surgery

Identifiers

PMID33441102
PMCPMC7805183
OpenAlexW3119828270

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.